Advances in the physiology of gastric emptying
There have been many recent advances in the understanding of various aspects of the
physiology of gastric motility and gastric emptying. Earlier studies had discovered the …
physiology of gastric motility and gastric emptying. Earlier studies had discovered the …
Glucose variability: how does it work?
A growing body of evidence points to the role of glucose variability (GV) in the development
of the microvascular and macrovascular complications of diabetes. In this review, we …
of the microvascular and macrovascular complications of diabetes. In this review, we …
Diabetes and aortic aneurysm: current state of the art
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …
curative treatment available relies on surgical approaches; drug-based therapies are …
Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease
Z Liu, RA Khalil - Biochemical pharmacology, 2018 - Elsevier
Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …
Identifying the mechanisms of VSM contraction has been a major research goal in order to …
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes
Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Cardiovascular disease (CVD) continues to be the primary cause of global mortality.
Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and …
Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and …
Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation
M Martín-Aragón Baudel, VA Flores-Tamez… - Circulation …, 2022 - Am Heart Assoc
Background: L-type CaV1. 2 channels undergo cooperative gating to regulate cell function,
although mechanisms are unclear. This study tests the hypothesis that phosphorylation of …
although mechanisms are unclear. This study tests the hypothesis that phosphorylation of …
Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle
M Nieves-Cintrón, VA Flores-Tamez, T Le… - Cellular and Molecular …, 2021 - Springer
Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
[HTML][HTML] Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease
Birth defects are the leading cause of infant mortality, and they are caused by a combination
of genetic and environmental factors. Environmental risk factors may contribute to birth …
of genetic and environmental factors. Environmental risk factors may contribute to birth …
[HTML][HTML] Dihydromyricetin protects against high glucose-induced endothelial dysfunction: Role of HIF-1α/ROR2/NF-κB
Objectives Dihydromyricetin (DHM), a natural flavonoid isolated from vine tea with anti-
inflammatory activity was evaluated for its ability to prevent vascular endothelial dysfunction …
inflammatory activity was evaluated for its ability to prevent vascular endothelial dysfunction …