The tumor microenvironment (TME) is a complex system composed of multiple cells, such as
non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal …

Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …

Connexin family proteins assemble into hexameric hemichannels in the cell membrane. The
hemichannels dock together between two adjacent membranes to form gap junction …

Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …

It is well known that tumours arising in different organs are innervated and that 'perineural
invasion'(cancer cells escaping from the tumour by following the nerve trunk) is a negative …

In myelinating Schwann cells, connection between myelin layers is mediated by gap
junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs) …

Bladder cancer (BCa) is one of the most prevalent cancers worldwide. The effectiveness of
intravesical therapy for bladder cancer, however, is limited due to the short dwell time and …

Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which
require enormous resources in both money and time. In silico models have been developed …

The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …