Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors
which share a common topology of seven transmembrane domains and modulate a variety …

Microbial nucleic acids are critical for the induction of innate immune responses, a host
defense mechanism against infection by microbes. Recent studies have indicated that …

Vertebrate glycoproteins and glycolipids are synthesized in complex biosynthetic pathways
localized predominantly within membrane compartments of the secretory pathway. The …

A robust and efficient cellular response to lysosomal membrane damage prevents leakage
from the lysosome lumen into the cytoplasm. This response is understood to happen through …

Translational readthrough gives rise to low abundance proteins with C-terminal extensions
beyond the stop codon. To identify functional translational readthrough, we estimated the …

Inadequate availability of inorganic phosphate (Pi) in the rhizosphere is a common
challenge to plants, which activate metabolic and developmental responses to maximize Pi …

Secreted proteins, such as hormones or cytokines, are key mediators in multicellular
organisms. Response of protein secretion based on transcriptional control is rather slow, as …

Cargo traffic through the Golgi apparatus is mediated by cisternal maturation, but it remains
largely unclear how the cis-cisternae, the earliest Golgi sub-compartment, is generated and …

Prediction of protein localization plays an important role in understanding protein function
and mechanisms. In this paper, we propose a general deep learning-based localization …