FAM20C is a gene coding for a protein kinase that targets SXE/pS motifs on different
phosphoproteins belonging to diverse tissues. Pathogenic variants of FAM20C are …

Otosclerosis is a relatively common cause of hearing impairment, characterized by abnormal
bone remodeling of the middle and inner ear. In about 50–60% of the patients, the disease …

Otosclerosis is one of the most common causes of conductive hearing loss, affecting 0.3% of
the population. It typically presents in adulthood and half of the patients have a positive …

Bone remodeling of the auditory ossicles and the otic capsule is highly restricted and tightly
controlled by the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa-Β ligand …

FAM20C (family with sequence similarity 20, member C) is a serine/threonine-specific
protein kinase that is ubiquitously expressed and mainly associated with biomineralization …

The development of skeletal muscle are complicated processes involving genes responsible
for proper muscle morphology, contractility, cell proliferation, differentiation, interactions …

To maintain an optimal body content of phosphorus throughout postnatal life, variable
phosphate absorption from food must be finely matched with urinary excretion. This amazing …

Otosclerosis is one of the most common causes of hearing loss in young adults. It has a
prevalence of 0.3–0.4% in the European population. Clinical symptoms usually occur …

In this study, we investigated the association of ACAN variants with otosclerosis, a frequent
cause of hearing loss among young adults. We sequenced the coding, 5′-UTR and 3 …

Background Otosclerosis (OTSC) is among the most common causes of a late-onset hearing
loss in adults and is characterized by an abnormal bone growth in the otic capsule …