Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

Abstract Resting-state functional Magnetic Resonance Imaging (rsfMRI) of the human brain
has revealed multiple large-scale neural networks within a hierarchical and complex …

Recent large-scale collaborations are generating major surveys of cell types and
connections in the mouse brain, collecting large amounts of data across modalities, spatial …

Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …

Three-dimensional digital brain atlases represent an important new generation of
neuroinformatics tools for understanding complex brain anatomy, assigning location to …

Laboratory mouse models represent a powerful tool to elucidate the biological foundations
of disease, but translation to and from human studies rely upon valid cross-species …

Over the last decade, several papers have focused on the construction of highly detailed
mouse high field magnetic resonance image (MRI) templates via non-linear registration to …

Over the past decade there has been an enormous progress in our understanding of fluid
and solute transport in the central nervous system (CNS). This is due to a number of factors …

Purpose Dynamic contrast‐enhanced MRI (DCE‐MRI) represents the only available
approach for glymphatic cerebrospinal fluid (CSF) flow 3D mapping in the brain of living …