Immune adaptations that maintain homeostasis with the intestinal microbiota
LV Hooper, AJ Macpherson - Nature Reviews Immunology, 2010 - nature.com
Humans harbour nearly 100 trillion intestinal bacteria that are essential for health. Millions of
years of co-evolution have moulded this human–microorganism interaction into a symbiotic …
years of co-evolution have moulded this human–microorganism interaction into a symbiotic …
T follicular helper cells in autoimmune disorders
T follicular helper (Tfh) cells are a distinct subset of CD4+ T lymphocytes, specialized in B
cell help and in regulation of antibody responses. They are required for the generation of …
cell help and in regulation of antibody responses. They are required for the generation of …
International Consensus Document (ICON): common variable immunodeficiency disorders
FA Bonilla, I Barlan, H Chapel… - The Journal of …, 2016 - jaci-inpractice.org
The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …
coalition among the American Academy of Allergy, Asthma & Immunology; the European …
[HTML][HTML] Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: a large patient cohort study
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently
described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD …
described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD …
Clinical picture and treatment of 2212 patients with common variable immunodeficiency
B Gathmann, N Mahlaoui, L Gérard… - Journal of Allergy and …, 2014 - Elsevier
Background Common variable immunodeficiency (CVID) is an antibody deficiency with an
equal sex distribution and a high variability in clinical presentation. The main features …
equal sex distribution and a high variability in clinical presentation. The main features …
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like
anchor protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral …
anchor protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral …
Morbidity and mortality in common variable immune deficiency over 4 decades
ES Resnick, EL Moshier, JH Godbold… - Blood, The Journal …, 2012 - ashpublications.org
The demographics, immunologic parameters, medical complications, and mortality statistics
from 473 subjects with common variable immune deficiency followed over 4 decades in New …
from 473 subjects with common variable immune deficiency followed over 4 decades in New …
Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis
H Ho, C Cunningham-Rundles - Frontiers in immunology, 2020 - frontiersin.org
Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …
Current genetic landscape in common variable immune deficiency
H Abolhassani, L Hammarström… - Blood, The Journal …, 2020 - ashpublications.org
Using whole-exome sequencing to examine the genetic causes of immune deficiency in 235
common variable immunodeficiency (CVID) patients seen in the United States (Mount Sinai …
common variable immunodeficiency (CVID) patients seen in the United States (Mount Sinai …
Primary immunodeficiencies
LD Notarangelo - Journal of Allergy and Clinical Immunology, 2010 - Elsevier
In the last years, advances in molecular genetics and immunology have resulted in the
identification of a growing number of genes causing primary immunodeficiencies (PIDs) in …
identification of a growing number of genes causing primary immunodeficiencies (PIDs) in …