Methyltransferases: functions and applications

E Abdelraheem, B Thair, RF Varela… - …, 2022 - Wiley Online Library
In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

Targeting metalloenzymes for therapeutic intervention

AY Chen, RN Adamek, BL Dick, CV Credille… - Chemical …, 2018 - ACS Publications
Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Stretchable, self-healing and tissue-adhesive zwitterionic hydrogels as strain sensors for wireless monitoring of organ motions

X Pei, H Zhang, Y Zhou, L Zhou, J Fu - Materials Horizons, 2020 - pubs.rsc.org
Skin-inspired sensors have great potential applications in wearable and implantable
devices to monitor human motions. Robust tissue adhesion, fatigue resistance, and …

Mussel-inspired adhesive and tough hydrogel based on nanoclay confined dopamine polymerization

L Han, X Lu, K Liu, K Wang, L Fang, LT Weng… - ACS …, 2017 - ACS Publications
Adhesive hydrogels are attractive biomaterials for various applications, such as electronic
skin, wound dressing, and wearable devices. However, fabricating a hydrogel with both …

Highly stretchable and biocompatible strain sensors based on mussel-inspired super-adhesive self-healing hydrogels for human motion monitoring

X Jing, HY Mi, YJ Lin, E Enriquez… - … applied materials & …, 2018 - ACS Publications
Integrating multifunctionality such as adhesiveness, stretchability, and self-healing ability on
a single hydrogel has been a challenge and is a highly desired development for various …

Advances in applying computer-aided drug design for neurodegenerative diseases

MM Salman, Z Al-Obaidi, P Kitchen, A Loreto… - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …

SAM/SAH analogs as versatile tools for SAM-dependent methyltransferases

J Zhang, YG Zheng - ACS chemical biology, 2016 - ACS Publications
S-Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of
methionine and adenosine. As the second largest cofactor in the human body, its major …

The concise guide to PHARMACOLOGY 2013/14: enzymes

SPH Alexander, HE Benson… - British Journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

A Halogen-Atom Transfer (XAT)-Based Approach to Indole Synthesis Using Aryl Diazonium Salts and Alkyl Iodides

S Govaerts, K Nakamura, T Constantin… - Organic Letters, 2022 - ACS Publications
Indoles are among the most important N-heterocycles in pharmaceuticals. Here, we present
an alternative to the classic Fischer indole synthesis based on the radical coupling between …

Recent developments in new therapeutic agents against Alzheimer and Parkinson diseases: in-silico approaches

P Cruz-Vicente, LA Passarinha, S Silvestre, E Gallardo - Molecules, 2021 - mdpi.com
Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease
(PD), are becoming increasingly more common and are recognized as a social problem in …