The technological landscape and applications of single-cell multi-omics
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …
simultaneously integrating various single-modality omics methods that profile the …
Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
Long noncoding RNA in cancer: wiring signaling circuitry
C Lin, L Yang - Trends in cell biology, 2018 - cell.com
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …
human genome, may hold missing drivers of cancer and have gained attention recently as a …
lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer
We characterized the epigenetic landscape of genes encoding long noncoding RNAs
(lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island …
(lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island …
Potential of long non‐coding RNAs in cancer patients: from biomarkers to therapeutic targets
S Chandra Gupta… - International journal of …, 2017 - Wiley Online Library
Because of high specificity and easy detection in the tissues, serum, plasma, urine and
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …
Risk SNP-mediated promoter-enhancer switching drives prostate cancer through lncRNA PCAT19
The prostate cancer (PCa) risk-associated SNP rs11672691 is positively associated with
aggressive disease at diagnosis. We showed that rs11672691 maps to the promoter of a …
aggressive disease at diagnosis. We showed that rs11672691 maps to the promoter of a …
ONECUT2 is a driver of neuroendocrine prostate cancer
Neuroendocrine prostate cancer (NEPC), a lethal form of the disease, is characterized by
loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which …
loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which …
Transsulfuration activity can support cell growth upon extracellular cysteine limitation
Cysteine acts both as a building unit for protein translation and as the limiting substrate for
glutathione synthesis to support the cellular antioxidant system. In addition to transporter …
glutathione synthesis to support the cellular antioxidant system. In addition to transporter …
The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases
AJ Alsheikh, S Wollenhaupt, EA King, J Reeb… - BMC medical …, 2022 - Springer
Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …
created a critical need to experimentally validate the disease-associated variants, 90% of …
LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex
Z Shang, J Yu, L Sun, J Tian, S Zhu… - Nucleic acids …, 2019 - academic.oup.com
In PTEN-deficient prostate cancers, AKT signaling may be activated upon suppression of
androgen receptor signaling. Activation of AKT as well as NF-κB signaling involves a key …
androgen receptor signaling. Activation of AKT as well as NF-κB signaling involves a key …