Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Nitric oxide and its production by iNOS is an established mechanism critical to tumor
promotion or suppression. Macrophages have important roles in immunity, development …

Collagens in the extracellular matrix (ECM) provide a physical barrier to tumor immune
infiltration, while also acting as a ligand for immune inhibitory receptors. Transforming …

Tumor-associated macrophages are a major constituent of malignant tumors and are known
to stimulate key steps in tumor progression. In our review in this journal in 2006, we …

Despite the great progress in translational research concerning skin wound healing in the
last few decades, no animal model fully predicts all clinical outcomes. The mouse is the most …

The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

Cancer cell dissemination during very early stages of breast cancer proceeds through poorly
understood mechanisms. Here we show, in a mouse model of HER2+ breast cancer, that a …

Mononuclear phagocyte plasticity includes the expression of functions related to the
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …

Animal tissues are made up of multiple cell types that are increasingly well-characterized,
yet our understanding of the core principles that govern tissue organization is still …

Breast cancer arising at a young age is relatively uncommon, particularly in the developed
world. Several studies have demonstrated that younger patients often experience a more …