[HTML][HTML] The safety and anti-ageing effects of nicotinamide mononucleotide in human clinical trials: an update
Q Song, X Zhou, K Xu, S Liu, X Zhu, J Yang - Advances in nutrition, 2023 - Elsevier
The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …
[HTML][HTML] Growth-coupled enzyme engineering through manipulation of redox cofactor regeneration
Enzymes need to be efficient, robust, and highly specific for their effective use in commercial
bioproduction. These properties can be introduced using various enzyme engineering …
bioproduction. These properties can be introduced using various enzyme engineering …
Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide
Z Huang, N Li, S Yu, W Zhang, T Zhang… - ACS Synthetic …, 2022 - ACS Publications
Research studies on NAD+ have proven its crucial role in aging and disease. Nicotinamide
mononucleotide (NMN), as the key intermediate of NAD+, plays a significant role in …
mononucleotide (NMN), as the key intermediate of NAD+, plays a significant role in …
Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide
Abstract β-Nicotinamide mononucleotide (NMN) is, one of the nucleotide compounds, a
precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop …
precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop …
Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform
Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …
Streamlining design, engineering, and applications of nicotinamide riboside kinase for sustainable biosynthesis of nicotinamide mononucleotide in flow
F Cheng, XH Wu, H Li, KX Li, Q Guo… - ACS Sustainable …, 2023 - ACS Publications
The market demand for β-nicotinamide mononucleotide (NMN), an antiaging health product,
is rapidly expanding. Consequently, there is an urgent requirement for an environment …
is rapidly expanding. Consequently, there is an urgent requirement for an environment …
Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide
Y Liu, M Yasawong, B Yu - Microbial Biotechnology, 2021 - Wiley Online Library
The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme
for cellular redox reactions, NAD. Administration of NMN is reported to improve various …
for cellular redox reactions, NAD. Administration of NMN is reported to improve various …
Biosynthesis of a therapeutically important nicotinamide mononucleotide through a phosphoribosyl pyrophosphate synthetase 1 and 2 engineered strain of …
A Maharjan, M Singhvi, BS Kim - ACS Synthetic Biology, 2021 - ACS Publications
Nicotinamide mononucleotide (NMN), a precursor of NAD+, can be synthesized by the
conversion of nicotinamide with the help of nicotinamide phosphoribosyl transferase …
conversion of nicotinamide with the help of nicotinamide phosphoribosyl transferase …
A holistic approach for process intensification of nicotinamide mononucleotide production via high cell density cultivation under exponential feeding strategy
Nicotinamide mononucleotide (NMN) subsists in all living organisms and has drawn
tremendous attention as a nutraceutical and pharmaceutical product for several diseases …
tremendous attention as a nutraceutical and pharmaceutical product for several diseases …
Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase
Noncanonical cofactor biomimetics (NCBs) such as nicotinamide mononucleotide (NMN+)
provide enhanced scalability for biomanufacturing. However, engineering enzymes to …
provide enhanced scalability for biomanufacturing. However, engineering enzymes to …