Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …

BACKGROUND Although laboratory procedures, along with culture media formulations,
have improved over the past two decades, the issue remains that human IVF is performed in …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …

The ability to sequence whole genomes has taught us that our knowledge with respect to
gene function is rather limited with typically 30–40% of open reading frames having no …

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …

BACKGROUND Transfer of more than a single embryo in an IVF cycle comes with the finite
possibility of a multiple gestation. Even a twin pregnancy confers significant risk to both …

Recent studies link changes in energy metabolism with the fate of pluripotent stem cells
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …

This review uses nutritional markers of normal and impaired development to address the
question; what makes a viable mammalian preimplantation embryo? Resolution of this …

BACKGROUND: IVF is limited by low success rates and an unacceptably high multiple
pregnancy rate. These outcomes would be improved significantly if a single embryo of high …

Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal
disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment …