Recurrent implantation failure: definition and management
C Coughlan, W Ledger, Q Wang, F Liu… - Reproductive …, 2014 - Elsevier
Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …
The effects of chemical and physical factors on mammalian embryo culture and their importance for the practice of assisted human reproduction
PL Wale, DK Gardner - Human reproduction update, 2016 - academic.oup.com
BACKGROUND Although laboratory procedures, along with culture media formulations,
have improved over the past two decades, the issue remains that human IVF is performed in …
have improved over the past two decades, the issue remains that human IVF is performed in …
[PDF][PDF] Metabolism of the preimplantation embryo: 40 years on
HJ Leese - Reproduction, 2012 - scholar.archive.org
This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …
progressed since the pioneering work on this topic in the late 1960s and early 1970s …
Metabolomics: current technologies and future trends
The ability to sequence whole genomes has taught us that our knowledge with respect to
gene function is rather limited with typically 30–40% of open reading frames having no …
gene function is rather limited with typically 30–40% of open reading frames having no …
Human embryos from overweight and obese women display phenotypic and metabolic abnormalities
C Leary, HJ Leese, RG Sturmey - Human reproduction, 2015 - academic.oup.com
STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …
Diagnosis of human preimplantation embryo viability
DK Gardner, M Meseguer, C Rubio… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Transfer of more than a single embryo in an IVF cycle comes with the finite
possibility of a multiple gestation. Even a twin pregnancy confers significant risk to both …
possibility of a multiple gestation. Even a twin pregnancy confers significant risk to both …
Pluripotent stem cell energy metabolism: an update
T Teslaa, MA Teitell - The EMBO journal, 2015 - embopress.org
Recent studies link changes in energy metabolism with the fate of pluripotent stem cells
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …
Quiet please, do not disturb: a hypothesis of embryo metabolism and viability
HJ Leese - Bioessays, 2002 - Wiley Online Library
This review uses nutritional markers of normal and impaired development to address the
question; what makes a viable mammalian preimplantation embryo? Resolution of this …
question; what makes a viable mammalian preimplantation embryo? Resolution of this …
Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover
DR Brison, FD Houghton, D Falconer… - Human …, 2004 - academic.oup.com
BACKGROUND: IVF is limited by low success rates and an unacceptably high multiple
pregnancy rate. These outcomes would be improved significantly if a single embryo of high …
pregnancy rate. These outcomes would be improved significantly if a single embryo of high …
[HTML][HTML] Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology
V Van Hoeck, RG Sturmey, P Bermejo-Alvarez… - PloS one, 2011 - journals.plos.org
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal
disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment …
disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment …