Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice
O Sirozh, A Saez-Mas, B Jung, L Sanchez-Burgos… - Molecular Cell, 2024 - cell.com
Nucleolar stress (NS) has been associated with age-related diseases such as cancer or
neurodegeneration. To investigate how NS triggers toxicity, we used (PR) n arginine-rich …
neurodegeneration. To investigate how NS triggers toxicity, we used (PR) n arginine-rich …
The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ
Background PolyQ diseases are autosomal dominant neurodegenerative disorders caused
by the expansion of CAG repeats. While of slow progression, these diseases are ultimately …
by the expansion of CAG repeats. While of slow progression, these diseases are ultimately …