Evolving concepts on bradykinesia

M Bologna, G Paparella, A Fasano, M Hallett… - Brain, 2020 - academic.oup.com
Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …

[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review

Z Yin, G Zhu, B Zhao, Y Bai, Y Jiang… - Neurobiology of …, 2021 - Elsevier
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …

Driving motor cortex oscillations modulates bradykinesia in Parkinson's disease

A Guerra, D Colella, M Giangrosso, A Cannavacciuolo… - Brain, 2022 - academic.oup.com
In patients with Parkinson's disease, beta (β) and gamma (γ) oscillations are altered in the
basal ganglia, and this abnormality contributes to the pathophysiology of bradykinesia …

[HTML][HTML] Spectral and spatial distribution of subthalamic beta peak activity in Parkinson's disease patients

N Darcy, R Lofredi, B Al-Fatly, WJ Neumann… - Experimental …, 2022 - Elsevier
Current efforts to optimise subthalamic deep brain stimulation in Parkinson's disease
patients aim to harness local oscillatory activity in the beta frequency range (13–35 Hz) as a …

[HTML][HTML] Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation

T Merk, V Peterson, R Köhler, S Haufe… - Experimental …, 2022 - Elsevier
Sensing enabled implantable devices and next-generation neurotechnology allow real-time
adjustments of invasive neuromodulation. The identification of symptom and disease …

[HTML][HTML] Redefining bradykinesia

M Bologna, AJ Espay, A Fasano… - … : official journal of the …, 2023 - ncbi.nlm.nih.gov
Recognizing and characterizing bradykinesia is a critical issue in movement disorders.
Bradykinesia is the core symptom for the definition of parkinsonism and for the diagnosis of …

Debugging adaptive deep brain stimulation for Parkinson's disease

S Little, P Brown - Movement Disorders, 2020 - Wiley Online Library
Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease.
In adaptive DBS, stimulation is titrated according to feedback about clinical state and …

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients

R Lofredi, L Okudzhava, F Irmen, C Brücke… - npj Parkinson's …, 2023 - nature.com
Pathologically increased beta power has been described as a biomarker for Parkinson's
disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we …

Diurnal modulation of subthalamic beta oscillatory power in Parkinson's disease patients during deep brain stimulation

JJ van Rheede, LK Feldmann, JL Busch… - npj Parkinson's …, 2022 - nature.com
Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson's
disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS) …

Proceedings of the eighth annual deep brain stimulation think tank: advances in optogenetics, ethical issues affecting DBS research, neuromodulatory approaches for …

V Vedam-Mai, K Deisseroth, J Giordano… - Frontiers in Human …, 2021 - frontiersin.org
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to
address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters …