Ovarian cancer is the second most common cause of gynecologic cancer death in women
around the world. The outcomes are complicated, because the disease is often diagnosed …

Onconephrology is a new subspecialty of nephrology that recognizes the important
intersections of kidney disease with cancer. This intersection takes many forms and includes …

PURPOSE: To evaluate the relative effect of percent maximal cytoreductive surgery and
other prognostic variables on survival among cohorts of patients with advanced-stage …

Purpose: In randomized trials the combination of cisplatin and paclitaxel was superior to
cisplatin and cyclophosphamide in advanced-stage epithelial ovarian cancer. Although in …

Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to
be in widespread clinical use especially for management of tumors of the ovary, testes, and …

The vast amount of basic research on platinum coordination complexes has produced, over
the past 25 years, several thousand new molecules for preclinical screening and 28 …

Since the introduction of platinum-based combination chemotherapy, particularly cisplatin,
the outcome of the treatment of many solid tumours has changed. The leading platinum …

Objective. Despite correlation between the completeness of surgical cytoreduction and
survival for patients with advanced ovarian cancer, relatively few undergo complete …

The narrow therapeutic index of anticancer drugs presents a clinical dilemma when these
agents are administered to patients with impaired or unstable renal function. The purpose of …

Most anticancer drugs are characterised by a steep dose–response relationship and narrow
therapeutic window. Inter-individual pharmacokinetic (PK) variability is often substantial. The …