Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

Articular cartilage is a remarkable tissue whose sophisticated composition and architecture
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …

Fibroblast activation protein (Fap) is a serine protease that degrades denatured type I
collagen, α2-antiplasmin and FGF21. Fap is highly expressed in bone marrow stromal cells …

Mesenchymal stem cell derived extracellular matrix (MSC-ECM) is a natural biomaterial with
robust bioactivity and good biocompatibility, and has been studied as a scaffold for tissue …

Purpose To systematically review and evaluate novel clinical data following microfracture
treatment of knee articular cartilage defects. Methods A systematic review was performed by …

Purpose To compare the midterm clinical outcomes of anteromedialization tibial tubercle
osteotomy combined with medial patellofemoral ligament reconstruction (TTO+ MPFLR) with …

Background and purpose—Cartilage damage can develop due to trauma, resulting in focal
chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized …

В последние годы наметилась тенденция к изменению клинической концепции
остеоартрита (ОА). Очень долго это заболевание рассматривалось как «возрастная …

Osteochondral (OC) defects are debilitating joint injuries characterized by the loss of full
thickness articular cartilage along with the underlying calcified cartilage through to the …

Knee pain is second only to the back as the most commonly reported area of pain in the
human body. With an overall prevalence of 46.2%, its impact on disability, lost productivity …