Lung cancer is the most often diagnosed cancer in the world and the most frequent cause of
cancer death. The prognosis for lung cancer is relatively poor and 75% of patients are …

Lung cancer is the most common malignancy and cause of cancer deaths worldwide, owing
to the dismal prognosis for most affected patients. Phosphatase and tensin homolog deleted …

Notch signaling represents a key mechanism mediating cancer metastasis and stemness.
To understand how Notch signaling is overactivated to couple tumor metastasis and self …

Context.—Needle biopsy of diseased tissue is an essential diagnostic tool that is becoming
even more important as precision medicine develops. However, the capability of this …

Rapid advancements in next-generation sequencing (ngs) technology have created an
unprecedented opportunity to decipher the molecular profile of tumours to more effectively …

Tumour suppressor genes play a cardinal role in the development of a large array of human
cancers, including lung cancer, which is one of the most frequently diagnosed cancers …

Purpose Targeted therapy of ALK in patients with metastatic nonsquamous non–small-cell
lung cancer (NSCLC) and ALK rearrangements improves outcomes compared with …

Lung cancer is the leading cause of cancer-related deaths among men and women. γ-
Secretase inhibitors, a class of small-molecule compounds that target the Notch pathway …

The management of patients with advanced non-small-cell lung cancer (NSCLC) is
becoming increasingly complex, with the identification of driver mutations/rearrangements …

Introduction To date, for all non-small cell lung cancer (NSCLC) cases, it is recommended to
test for driver alterations to identify actionable therapeutic targets. In this light …