Mechanisms of red blood cell transfusion‐related immunomodulation
Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …
patients in whom both systemic inflammation and immune suppression are associated with …
Iron in the tumor microenvironment—connecting the dots
C Pfeifhofer-Obermair, P Tymoszuk, V Petzer… - Frontiers in …, 2018 - frontiersin.org
Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …
Prolonged red cell storage before transfusion increases extravascular hemolysis
F Rapido, GM Brittenham… - The Journal of …, 2017 - Am Soc Clin Investig
BACKGROUND. Some countries have limited the maximum allowable storage duration for
red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 …
red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 …
Iron metabolism and brain development in premature infants
Y Wang, Y Wu, T Li, X Wang, C Zhu - Frontiers in physiology, 2019 - frontiersin.org
Iron is important for a remarkable array of essential functions during brain development, and
it needs to be provided in adequate amounts, especially to preterm infants. In this review …
it needs to be provided in adequate amounts, especially to preterm infants. In this review …
Anemia of prematurity: how low is too low?
CC Cibulskis, A Maheshwari, R Rao… - Journal of …, 2021 - nature.com
Anemia of prematurity (AOP) is a common condition with a well-described chronology, nadir
hemoglobin levels, and timeline of recovery. However, the underlying pathophysiology and …
hemoglobin levels, and timeline of recovery. However, the underlying pathophysiology and …
Red blood cell transfusions can induce proinflammatory cytokines in preterm infants
C Dani, C Poggi, E Gozzini, V Leonardi, A Sereni… - …, 2017 - Wiley Online Library
BACKGROUND The risk of developing red blood cell (RBC) transfusion–associated
necrotizing enterocolitis (TANEC) in preterm infants has recently been emphasized. Our aim …
necrotizing enterocolitis (TANEC) in preterm infants has recently been emphasized. Our aim …
Effect of high-dose erythropoietin on blood transfusions in extremely low gestational age neonates: post hoc analysis of a randomized clinical trial
Importance Extremely preterm infants are among the populations receiving the highest
levels of transfusions. Erythropoietin has not been recommended for premature infants …
levels of transfusions. Erythropoietin has not been recommended for premature infants …
Management of anaemia in pre‐term infants
M Saito‐Benz, P Flanagan… - British journal of …, 2020 - Wiley Online Library
Pre‐term infants have one of the highest transfusion requirements within the hospital‐
setting. The vast majority of blood transfusions performed in Neonatal Intensive Care Units …
setting. The vast majority of blood transfusions performed in Neonatal Intensive Care Units …
Assessment of micronutrient status in critically ill children: challenges and opportunities
DT Dao, L Anez-Bustillos, BS Cho, Z Li, M Puder… - Nutrients, 2017 - mdpi.com
Micronutrients refer to a group of organic vitamins and inorganic trace elements that serve
many functions in metabolism. Assessment of micronutrient status in critically ill children is …
many functions in metabolism. Assessment of micronutrient status in critically ill children is …
New frontiers in neonatal red blood cell transfusion research
CM Stark, SE Juul - Journal of Perinatology, 2023 - nature.com
Red blood cell (RBC) transfusions are common in neonates requiring intensive care. Recent
studies have compared restricted versus liberal transfusion guidelines, but limitations exist …
studies have compared restricted versus liberal transfusion guidelines, but limitations exist …