Mechanisms of red blood cell transfusion‐related immunomodulation

KE Remy, MW Hall, J Cholette, NP Juffermans… - …, 2018 - Wiley Online Library
Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …

Iron in the tumor microenvironment—connecting the dots

C Pfeifhofer-Obermair, P Tymoszuk, V Petzer… - Frontiers in …, 2018 - frontiersin.org
Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Prolonged red cell storage before transfusion increases extravascular hemolysis

F Rapido, GM Brittenham… - The Journal of …, 2017 - Am Soc Clin Investig
BACKGROUND. Some countries have limited the maximum allowable storage duration for
red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 …

Iron metabolism and brain development in premature infants

Y Wang, Y Wu, T Li, X Wang, C Zhu - Frontiers in physiology, 2019 - frontiersin.org
Iron is important for a remarkable array of essential functions during brain development, and
it needs to be provided in adequate amounts, especially to preterm infants. In this review …

Anemia of prematurity: how low is too low?

CC Cibulskis, A Maheshwari, R Rao… - Journal of …, 2021 - nature.com
Anemia of prematurity (AOP) is a common condition with a well-described chronology, nadir
hemoglobin levels, and timeline of recovery. However, the underlying pathophysiology and …

Red blood cell transfusions can induce proinflammatory cytokines in preterm infants

C Dani, C Poggi, E Gozzini, V Leonardi, A Sereni… - …, 2017 - Wiley Online Library
BACKGROUND The risk of developing red blood cell (RBC) transfusion–associated
necrotizing enterocolitis (TANEC) in preterm infants has recently been emphasized. Our aim …

Effect of high-dose erythropoietin on blood transfusions in extremely low gestational age neonates: post hoc analysis of a randomized clinical trial

SE Juul, PT Vu, BA Comstock, R Wadhawan… - JAMA …, 2020 - jamanetwork.com
Importance Extremely preterm infants are among the populations receiving the highest
levels of transfusions. Erythropoietin has not been recommended for premature infants …

Management of anaemia in pre‐term infants

M Saito‐Benz, P Flanagan… - British journal of …, 2020 - Wiley Online Library
Pre‐term infants have one of the highest transfusion requirements within the hospital‐
setting. The vast majority of blood transfusions performed in Neonatal Intensive Care Units …

Assessment of micronutrient status in critically ill children: challenges and opportunities

DT Dao, L Anez-Bustillos, BS Cho, Z Li, M Puder… - Nutrients, 2017 - mdpi.com
Micronutrients refer to a group of organic vitamins and inorganic trace elements that serve
many functions in metabolism. Assessment of micronutrient status in critically ill children is …

New frontiers in neonatal red blood cell transfusion research

CM Stark, SE Juul - Journal of Perinatology, 2023 - nature.com
Red blood cell (RBC) transfusions are common in neonates requiring intensive care. Recent
studies have compared restricted versus liberal transfusion guidelines, but limitations exist …