[PDF][PDF] Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment

S Bahadoram, M Davoodi, S Hassanzadeh… - G Ital Nefrol, 2022 - researchgate.net
Renal cell carcinoma (RCC) is the most common type of urogenital cancer. It has a mortality
rate of 30-40% and is more commonly seen in men than women. In addition to gender, other …

Renal cell carcinoma

JJ Hsieh, MP Purdue, S Signoretti, C Swanton… - Nature reviews Disease …, 2017 - nature.com
Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and
accounts for> 90% of cancers in the kidney. The disease encompasses> 10 histological and …

Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase …

BI Rini, T Powles, MB Atkins, B Escudier… - The Lancet, 2019 - thelancet.com
Background A phase 2 trial showed improved progression-free survival for atezolizumab
plus bevacizumab versus sunitinib in patients with metastatic renal cell carcinoma who …

Cuproptosis-associated lncRNA establishes new prognostic profile and predicts immunotherapy response in clear cell renal cell carcinoma

S Xu, D Liu, T Chang, X Wen, S Ma, G Sun… - Frontiers in …, 2022 - frontiersin.org
Background: Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all kidney cancers
and has a poor prognosis. Recent studies have shown that copper-dependent, regulated …

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

MD Young, TJ Mitchell, FA Vieira Braga, MGB Tran… - science, 2018 - science.org
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it
defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 …

Comparison of immediate vs deferred cytoreductive nephrectomy in patients with synchronous metastatic renal cell carcinoma receiving sunitinib: the SURTIME …

A Bex, P Mulders, M Jewett, J Wagstaff… - JAMA …, 2019 - jamanetwork.com
Importance In clinical practice, patients with primary metastatic renal cell carcinoma (mRCC)
have been offered cytoreductive nephrectomy (CN) followed by targeted therapy, but the …

[HTML][HTML] Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers

J Jin, Y Xie, JS Zhang, JQ Wang, SJ Dai, W He… - Drug Resistance …, 2023 - Elsevier
Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial

TK Choueiri, B Escudier, T Powles, NM Tannir… - The lancet …, 2016 - thelancet.com
Background Cabozantinib is an oral inhibitor of tyrosine kinases including MET, VEGFR,
and AXL. The randomised phase 3 METEOR trial compared the efficacy and safety of …

Renal cancer

U Capitanio, F Montorsi - The Lancet, 2016 - thelancet.com
The diagnosis and management of renal cell carcinoma have changed remarkably rapidly.
Although the incidence of renal cell carcinoma has been increasing, survival has improved …

Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial

RJ Motzer, TE Hutson, H Glen, MD Michaelson… - The lancet …, 2015 - thelancet.com
Background Currently, metastatic renal cell carcinoma is treated with sequential single
agents targeting VEGF or mTOR. Here, we aimed to assess lenvatinib, everolimus, or their …