[HTML][HTML] Advanced tandem mass spectrometry in metabolomics and lipidomics—methods and applications
S Heiles - Analytical and Bioanalytical Chemistry, 2021 - Springer
Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …
Recent developments in gas-phase ion/ion reactions for analytical mass spectrometry
DJ Foreman, SA McLuckey - Analytical chemistry, 2019 - ACS Publications
While the study of reactions between oppositely charged ions has a long history, particularly
within the context of plasmas and interstellar chemistry, the exploitation of such reactions for …
within the context of plasmas and interstellar chemistry, the exploitation of such reactions for …
Toward complete structure elucidation of glycerophospholipids in the gas phase through charge inversion ion/ion chemistry
Shotgun lipidomics has recently gained popularity for lipid analysis. Conventionally, shotgun
analysis of glycerophospholipids via direct electrospray ionization tandem mass …
analysis of glycerophospholipids via direct electrospray ionization tandem mass …
[HTML][HTML] A lipidomic workflow capable of resolving sn-and C [double bond, length as m-dash] C location isomers of phosphatidylcholines
X Zhao, W Zhang, D Zhang, X Liu, W Cao, Q Chen… - Chemical …, 2019 - pubs.rsc.org
As a major class of mammalian lipids, phosphatidylcholines (PCs) often contain mixtures of
structural isomers, resulting from different lipogenesis pathways. Profiling PCs at the isomer …
structural isomers, resulting from different lipogenesis pathways. Profiling PCs at the isomer …
Next-generation Paternò–Büchi reagents for lipid analysis by mass spectrometry
The Paternò–Büchi (PB) reaction is a photochemical reaction involving [2+ 2] cycloaddition
between electronically excited carbonyl and carbon–carbon double bond (C═ C). It has …
between electronically excited carbonyl and carbon–carbon double bond (C═ C). It has …
Profiling of Cholesteryl Esters by Coupling Charge-Tagging Paternò–Büchi Reaction and Liquid Chromatography–Mass Spectrometry
X Xie, J Zhao, M Lin, JL Zhang, Y Xia - Analytical Chemistry, 2020 - ACS Publications
The profile of cholesteryl esters (CEs) is increasingly used in metabolic disease monitoring
due to the roles of CE in regulating the cholesterol level. While electrospray ionization …
due to the roles of CE in regulating the cholesterol level. While electrospray ionization …
Localization of carbon–carbon double bond and cyclopropane sites in cardiolipins via gas-phase charge inversion reactions
CE Randolph, DSM Shenault… - Journal of the …, 2020 - ACS Publications
Cardiolipins (CLs) are comprised of two phosphatic acid moieties bound to a central glycerol
backbone and are substituted with four acyl chains. Consequently, a vast number of distinct …
backbone and are substituted with four acyl chains. Consequently, a vast number of distinct …
Structural characterization of phospholipids and sphingolipids by in-source fragmentation MALDI/TOF mass spectrometry
HYJ Wang, FF Hsu - Analytical and bioanalytical chemistry, 2022 - Springer
Abstract Phospholipids (PLs) and sphingolipids (SLs) perform critical structural and
biological functions in cells. The structure of these lipids, including the stereospecificity and …
biological functions in cells. The structure of these lipids, including the stereospecificity and …
Differentiation and quantification of diastereomeric pairs of glycosphingolipids using gas-phase ion chemistry
HC Chao, SA McLuckey - Analytical chemistry, 2020 - ACS Publications
Glycosphingolipids (GSLs), including lyso-glycosphingolipids (lyso-GSLs) and cerebrosides
(HexCer), constitute a sphingolipid subclass. The diastereomerism between their …
(HexCer), constitute a sphingolipid subclass. The diastereomerism between their …
Enhancing detection and characterization of lipids using charge manipulation in electrospray ionization-tandem mass spectrometry
Heightened awareness regarding the implication of disturbances in lipid metabolism with
respect to prevalent human-related pathologies demands analytical techniques that provide …
respect to prevalent human-related pathologies demands analytical techniques that provide …