Extracellular vesicles in fungi: past, present, and future perspectives

J Rizzo, ML Rodrigues, G Janbon - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical
research fields. Many studies have reported the existence of EVs in all types of living cells …

Communication is key: extracellular vesicles as mediators of infection and defence during host–microbe interactions in animals and plants

H U. Stotz, D Brotherton, J Inal - FEMS microbiology reviews, 2022 - academic.oup.com
Extracellular vesicles (EVs) are now understood to be ubiquitous mediators of cellular
communication. In this review, we suggest that EVs have evolved into a highly regulated …

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

J Rizzo, SSW Wong, AD Gazi… - Journal of …, 2021 - Wiley Online Library
Whereas extracellular vesicle (EV) research has become commonplace in different
biomedical fields, this field of research is still in its infancy in mycology. Here we provide a …

The emerging role of extracellular vesicles in fungi: A double-edged sword

Y Lai, B Jiang, F Hou, X Huang, B Ling, H Lu… - Frontiers in …, 2023 - frontiersin.org
Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

Harnessing the immune response to fungal pathogens for vaccine development

A Rivera, J Lodge, C Xue - Annual review of microbiology, 2022 - annualreviews.org
Invasive fungal infections are emerging diseases that kill over 1.5 million people per year
worldwide. With the increase of immunocompromised populations, the incidence of invasive …

Protective effect of fungal extracellular vesicles against murine candidiasis

G Vargas, L Honorato, AJ Guimarães… - Cellular …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayered compartments released by virtually all living
cells, including fungi. Among the diverse molecules carried by fungal EVs, a number of …

Comparative molecular and immunoregulatory analysis of extracellular vesicles from Candida albicans and Candida auris

D Zamith-Miranda, HM Heyman, SP Couvillion… - Msystems, 2021 - Am Soc Microbiol
Candida auris is a recently described multidrug-resistant pathogenic fungus that is
increasingly responsible for health care-associated outbreaks across the world …

Immunological correlates of protection following vaccination with glucan particles containing Cryptococcus neoformans chitin deacetylases

R Wang, LVN Oliveira, D Lourenco, CL Gomez, CK Lee… - npj Vaccines, 2023 - nature.com
Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin
deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here …

Rearing and Maintenance of Galleria mellonella and Its Application to Study Fungal Virulence

C Firacative, A Khan, S Duan, K Ferreira-Paim… - Journal of Fungi, 2020 - mdpi.com
Galleria mellonella larvae have been widely used as alternative non-mammalian models for
the study of fungal virulence and pathogenesis. The larvae can be acquired in small …

Media matters! Alterations in the loading and release of Histoplasma capsulatum extracellular vesicles in response to different nutritional milieus

LG Cleare, D Zamith, HM Heyman… - Cellular …, 2020 - Wiley Online Library
Histoplasma capsulatum is a dimorphic fungus that most frequently causes pneumonia, but
can also disseminate and proliferate in diverse tissues. Histoplasma capsulatum has a …