Importance Approximately 20% to 30% of patients admitted to an intensive care unit have
sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids …

During septic shock, fluid therapy is aimed at increasing cardiac output and improving tissue
oxygenation, but it poses two problems: it has inconsistent and transient efficacy, and it has …

Fluid administration is a cornerstone of treatment of critically ill patients. The aim of this
review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms …

Sepsis causes significant morbidity and mortality worldwide. Resuscitation is a cornerstone
of management. This review covers five areas of evolving practice in the management of …

Introduction Fluid challenges are widely adopted in critically ill patients to reverse
haemodynamic instability. We reviewed the literature to appraise fluid challenge …

Importance Intravenous fluid administration is recommended to improve outcomes for
patients with septic shock. However, there are few data on fluid administration for patients …

There are several clinical practice guidelines concerning the use of fluid and vasoactive
drug therapies in critically ill adult patients, but the recommendations in these guidelines are …

Sepsis is a worldwide public health problem due to its high incidence and accompanying
mortality, morbidity, and financial burden. It is a major cause of admission to paediatric …

Rationale: Optimal infusion rate for fluid challenges in critically ill patients is unknown. A
large clinical trial comparing two different infusion rates yielded neutral results. Conditional …

Administration of intravenous fluids is among the most common interventions performed in
intensive care units (ICUs). The first description of fluids for resuscitation of a critically ill …