Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however,
the mechanism through which epigenetic regulation modulates intestinal epithelial integrity …

The association between chronic inflammation and cancer has long been recognized. The
inflammatory bowel disease ulcerative colitis frequently progresses to colon cancer; …

Aims: Intact intestinal epithelium is essential to maintain normal intestinal physiological
function. Irradiation-induced gastrointestinal syndrome or inflammatory bowel disease …

Intestinal barrier function defects and dysregulation of intestinal immune responses are two
key contributory factors in the pathogenesis of ulcerative colitis (UC). Phenazine …

Caspase-1 activation by inflammasome signaling scaffolds initiates inflammation and
antimicrobial responses. Caspase-1 proteolytically converts newly induced pro-interleukin 1 …

Lung cancer is one of the cancers with highest morbidity and mortality rates and the
metastasis of lung cancer is a leading cause of death. Mechanisms of lung cancer …

Precise control of inflammatory gene expression is critical for effective host defense without
excessive tissue damage. The principal regulator of inflammatory gene expression is …