Protein splicing of inteins: a powerful tool in synthetic biology
H Wang, L Wang, B Zhong, Z Dai - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Inteins are protein segments that are capable of enabling the ligation of flanking extein into a
new protein, a process known as protein splicing. Since its discovery, inteins have become …
new protein, a process known as protein splicing. Since its discovery, inteins have become …
Recent advances in molecular farming using monocot plants
Heterologous synthesis of proteins or peptides in plant-based systems, referred to as plant
molecular farming, is a practical and safe approach for the large-scale and cost-effective …
molecular farming, is a practical and safe approach for the large-scale and cost-effective …
KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3
H Soh, K Springer, K Doci… - Proceedings of the …, 2022 - National Acad Sciences
KCNQ2 and KCNQ3 channels are associated with multiple neurodevelopmental disorders
and are also therapeutic targets for neurological and neuropsychiatric diseases. For more …
and are also therapeutic targets for neurological and neuropsychiatric diseases. For more …
Inteins as drug targets and therapeutic tools
AM Tharappel, Z Li, H Li - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Multidrug-resistant pathogens are of significant concern in recent years. Hence new
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …
Molecular design of protein-based materials–state of the art, opportunities and challenges at the interface between materials engineering and synthetic biology
E Shire, AAB Coimbra, CB Ostria… - … Systems Design & …, 2024 - pubs.rsc.org
Structural proteins like silk, squid ring teeth, elastin, collagen, or resilin, among others, are
inspiring the development of new sustainable biopolymeric materials for applications …
inspiring the development of new sustainable biopolymeric materials for applications …
Inteins: A Swiss army knife for synthetic biology
Inteins are proteins found in nature that execute protein splicing. Among them, split inteins
stand out for their versatility and adaptability, presenting creative solutions for addressing …
stand out for their versatility and adaptability, presenting creative solutions for addressing …
Increasing the Scalability of Toxin–Intein Orthogonal Combinations
R López-Igual, P Dorado-Morales… - ACS Synthetic …, 2023 - ACS Publications
Inteins are proteins embedded into host proteins from which they are excised in an
autocatalytic reaction. Specifically, split inteins are separated into two independent …
autocatalytic reaction. Specifically, split inteins are separated into two independent …
Protein engineering for natural product biosynthesis: expanding diversity for therapeutic applications
In this dispensation of the fourth industrial revolution, protein engineering has become a
popular approach for increasing enzymatic activity, stability, and titer in the biosynthesis of …
popular approach for increasing enzymatic activity, stability, and titer in the biosynthesis of …
Intein inhibitors as novel antimicrobials: protein splicing in human pathogens, screening methods, and off-target considerations
Protein splicing is a post-translational process by which an intervening polypeptide, or
intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with …
intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with …
Calcimycin Inhibits Cryptococcus neoformans In Vitro and In Vivo by Targeting the Prp8 Intein Splicing
AM Tharappel, Z Li, YC Zhu, X Wu… - ACS infectious …, 2022 - ACS Publications
Drug resistance is a significant concern in the treatment of diseases, including
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …