Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …

Background Relatively high plasma levels of soluble urokinase-type plasminogen activator
receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor …

Focal segmental glomerulosclerosis (FSGS) is not a specific disease entity but a lesion that
primarily targets the podocyte. In a broad sense, the causes of the lesion can be divided into …

The development of post-transplantation antibodies against non-HLA autoantigens is
associated with rejection and decreased long-term graft survival. Although our knowledge of …

Background Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B
can explain the majority of cases of primary membranous nephropathy (MN). However …

More than 85% of children and adolescents (majority between 1–12 years old) with
idiopathic nephrotic syndrome show complete remission of proteinuria following daily …

High levels of circulating TNF and its receptors, TNFR1 and TNFR2, predict the progression
of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains …

Excess levels of protein in urine (proteinuria) is a hallmark of kidney disease that typically
occurs in conjunction with diabetes, hypertension, gene mutations, toxins or infections but …