Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
Focal segmental glomerulosclerosis
AZ Rosenberg, JB Kopp - Clinical Journal of the American Society …, 2017 - journals.lww.com
Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …
[HTML][HTML] Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond
JL Karnell, SA Rieder, R Ettinger, R Kolbeck - Advanced drug delivery …, 2019 - Elsevier
CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …
[HTML][HTML] Soluble urokinase receptor and chronic kidney disease
Background Relatively high plasma levels of soluble urokinase-type plasminogen activator
receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor …
receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor …
Therapeutic trials in adult FSGS: lessons learned and the road forward
AS De Vriese, JF Wetzels, RJ Glassock… - Nature reviews …, 2021 - nature.com
Focal segmental glomerulosclerosis (FSGS) is not a specific disease entity but a lesion that
primarily targets the podocyte. In a broad sense, the causes of the lesion can be divided into …
primarily targets the podocyte. In a broad sense, the causes of the lesion can be divided into …
The importance of non-HLA antibodies in transplantation
Q Zhang, EF Reed - Nature Reviews Nephrology, 2016 - nature.com
The development of post-transplantation antibodies against non-HLA autoantigens is
associated with rejection and decreased long-term graft survival. Although our knowledge of …
associated with rejection and decreased long-term graft survival. Although our knowledge of …
Serine protease HTRA1 as a novel target antigen in primary membranous nephropathy
LF Al-Rabadi, T Caza, C Trivin-Avillach… - Journal of the …, 2021 - journals.lww.com
Background Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B
can explain the majority of cases of primary membranous nephropathy (MN). However …
can explain the majority of cases of primary membranous nephropathy (MN). However …
Management of steroid-resistant nephrotic syndrome in children and adolescents
K Tullus, H Webb, A Bagga - The Lancet Child & Adolescent Health, 2018 - thelancet.com
More than 85% of children and adolescents (majority between 1–12 years old) with
idiopathic nephrotic syndrome show complete remission of proteinuria following daily …
idiopathic nephrotic syndrome show complete remission of proteinuria following daily …
Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury
CE Pedigo, GM Ducasa, F Leclercq… - The Journal of …, 2016 - Am Soc Clin Investig
High levels of circulating TNF and its receptors, TNFR1 and TNFR2, predict the progression
of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains …
of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains …
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease
Excess levels of protein in urine (proteinuria) is a hallmark of kidney disease that typically
occurs in conjunction with diabetes, hypertension, gene mutations, toxins or infections but …
occurs in conjunction with diabetes, hypertension, gene mutations, toxins or infections but …