Interferons: reprogramming the metabolic network against viral infection
K Raniga, C Liang - Viruses, 2018 - mdpi.com
Viruses exploit the host and induce drastic metabolic changes to ensure an optimal
environment for replication and the production of viral progenies. In response, the host has …
environment for replication and the production of viral progenies. In response, the host has …
[HTML][HTML] Human immunodeficiency virus (HIV)
GAC Blood - Transfusion medicine and hemotherapy, 2016 - ncbi.nlm.nih.gov
German Advisory Committee Blood (Arbeitskreis Blut), Subgroup 'Assessment of Pathogens
Transmissible by Blood'tein, TM) are derived. In addition to the structural proteins, the HIV …
Transmissible by Blood'tein, TM) are derived. In addition to the structural proteins, the HIV …
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …
Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells
E Pauls, A Ruiz, R Badia, M Permanyer… - The Journal of …, 2014 - journals.aai.org
Proliferating cells are preferentially susceptible to infection by retroviruses. Sterile α motif
and HD domain–containing protein-1 (SAMHD1) is a recently described deoxynucleotide …
and HD domain–containing protein-1 (SAMHD1) is a recently described deoxynucleotide …
Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells
The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency
viruses (SIVs and HIVs), is thought to improve viral infectivity of myeloid cells. We infected 35 …
viruses (SIVs and HIVs), is thought to improve viral infectivity of myeloid cells. We infected 35 …
SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation
J Wang, F Lu, XY Shen, Y Wu, L Zhao - Biochemical and biophysical …, 2014 - Elsevier
The function of dNTP hydrolase SAMHD1 as a viral restriction factor to inhibit the replication
of several viruses in human immune cells was well established. However, its regulation and …
of several viruses in human immune cells was well established. However, its regulation and …
Interferons induce expression of SAMHD1 in monocytes through down-regulation of miR-181a and miR-30a
M Riess, NV Fuchs, A Idica, M Hamdorf, E Flory… - Journal of Biological …, 2017 - ASBMB
SAMHD1 is a phosphohydrolase maintaining cellular dNTP homeostasis but also acts as a
critical regulator in innate immune responses due to its antiviral activity and association with …
critical regulator in innate immune responses due to its antiviral activity and association with …
SAMHD1 suppression of antiviral immune responses
SAMHD1 is a host triphosphohydrolase that degrades intracellular deoxynucleoside
triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents …
triphosphates (dNTPs) to a lower level that restricts viral DNA synthesis, and thus prevents …
SAMHD1's protein expression profile in humans
S Schmidt, K Schenkova, T Adam… - Journal of Leucocyte …, 2015 - academic.oup.com
The deoxynucleoside triphosphate triphosphohydrolase and 3′→ 5′ exonuclease
SAMHD1 restricts HIV-1 infection in noncycling hematopoietic cells in vitro, and SAMHD1 …
SAMHD1 restricts HIV-1 infection in noncycling hematopoietic cells in vitro, and SAMHD1 …
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain
Background In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1
persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates …
persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates …