The role of N-glycosylation modification in the pathogenesis of liver cancer

M Hu, R Zhang, J Yang, C Zhao, W Liu, Y Huang… - Cell Death & …, 2023 - nature.com
N-glycosylation is one of the most common types of protein modifications and it plays a vital
role in normal physiological processes. However, aberrant N-glycan modifications are …

The roles of junctional adhesion molecules (JAMs) in cell migration

J Wang, H Liu - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The review briefly summarizes the role of the family of adhesion molecules, JAMs (junctional
adhesion molecules), in various cell migration, covering germ cells, epithelial cells …

EGCG alleviated Mn exposure-caused carp kidney damage via trpm2-NLRP3-TNF-α-JNK pathway: Oxidative stress, inflammation, and tight junction dysfunction

Q Zhou, J Cui, Y Liu, L Gu, X Teng, Y Tang - Fish & shellfish immunology, 2023 - Elsevier
Manganese (Mn), an essential trace metal element in organisms. However, with extensive
use of Mn in industry and agriculture, Mn becomes a heavy metal pollutant in water.(−) …

Integrin α3 promotes TH17 cell polarization and extravasation during autoimmune neuroinflammation

E Park, WE Barclay, A Barrera, TC Liao… - Science …, 2023 - science.org
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
caused by CNS-infiltrating leukocytes, including TH17 cells that are critical mediators of …

The role and regulation of integrins in cell migration and invasion

MR Chastney, J Kaivola, VM Leppänen… - … Reviews Molecular Cell …, 2024 - nature.com
Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Exploring the role of CD151 in the tumor immune microenvironment: therapeutic and clinical perspectives

RR Malla, R Marni, A Chakraborty - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
CD151 is a transmembrane protein implicated in tumor progression and has been shown to
regulate various cellular and molecular mechanisms contributing to malignancy. More …

Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis

V Chilunda, J Weiselberg, S Martinez-Meza… - Frontiers in …, 2022 - frontiersin.org
HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV
(PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life …

Development of Integrin-Facilitated Bispecific Aptamer Chimeras for Membrane Protein Degradation

W Sun, H Zhang, W Xie, L Ma, Y Dang… - Journal of the …, 2024 - ACS Publications
The emergence of lysosome-targeting chimeras (LYTACs), which represents a promising
strategy for membrane protein degradation based on lysosomal pathways, has attracted …

F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?

P Kamola, A Babinska, T Przygodzki - Platelets, 2023 - Taylor & Francis
Abstract F11 receptor (F11R)/Junctional Adhesion Molecule–A (JAM-A) is a transmembrane
protein which belongs to the immunoglobulin superfamily of cell adhesion molecules …

CD151-enriched migrasomes mediate hepatocellular carcinoma invasion by conditioning cancer cells and promoting angiogenesis

K Zhang, Z Zhu, R Jia, NA Wang, M Shi, Y Wang… - Journal of Experimental …, 2024 - Springer
Background The tetraspanin family plays a pivotal role in the genesis of migrasomes, and
Tetraspanin CD151 is also implicated in neovascularization within tumorous contexts …