The biological function and the regulatory roles of wild-type p53-induced phosphatase 1 in immune system
L Shi, Q Tian, C Feng, P Zhang… - International Reviews of …, 2020 - Taylor & Francis
Wild-type p53-induced phosphatase 1 (WIP1) belongs to the protein phosphatase 2C
(PP2C) family and is a mammalian serine/threonine specific protein phosphatase to …
(PP2C) family and is a mammalian serine/threonine specific protein phosphatase to …
PARP-1 negatively regulates nucleolar protein pool and mitochondrial activity: a cell protective mechanism
A Ghorai, S Saha, BJ Rao - Genes and Environment, 2024 - Springer
Background Poly (ADP-ribose) polymerase-1 (PARP-1) is a pan nuclear protein that utilizes
NAD+ as a substrate for poly (ADP-ribosyl) ation reaction (PARylation), resulting in both auto …
NAD+ as a substrate for poly (ADP-ribosyl) ation reaction (PARylation), resulting in both auto …
Pharmacological inhibition of WIP1 sensitizes acute myeloid leukemia cells to the MDM2 inhibitor Nutlin-3a
MC Fontana, J Nanni, A Ghelli Luserna di Rorà… - Biomedicines, 2021 - mdpi.com
In acute myeloid leukemia (AML), the restoration of p53 activity through MDM2 inhibition
proved efficacy in combinatorial therapies. WIP1, encoded from PPM1D, is a negative …
proved efficacy in combinatorial therapies. WIP1, encoded from PPM1D, is a negative …
Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental …
JL Cunningham, J Frankovich, RA Dubin… - Developmental …, 2024 - karger.com
Acute onset of severe psychiatric symptoms or regression may occur in children with
premorbid neurodevelopmental disorders, although typically developing children can also …
premorbid neurodevelopmental disorders, although typically developing children can also …
[HTML][HTML] Proteomics and phosphoproteomics profiling in glutamatergic neurons and microglia in an iPSC model of Jansen de Vries Syndrome
JT Aguilan, E Pedrosa, H Dolstra, RN Baykara… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background: Jansen de Vries Syndrome (JdVS) is a rare neurodevelopmental disorder
(NDD) caused by gain-of-function (GOF) truncating mutations in PPM1D exons 5 or 6 …
(NDD) caused by gain-of-function (GOF) truncating mutations in PPM1D exons 5 or 6 …
ATR signalling mediates the prosurvival function of phospho-NPM against PIDDosome mediated cell death
We uncover a novel non-canonical function of ATR kinase in the control of PIDDosome
activation, and show that under normal cellular conditions involving no replication stress …
activation, and show that under normal cellular conditions involving no replication stress …
Uncovering Phosphorylation Circuitries That Control DNA Replication Fork Dynamics
J Badar - 2023 - search.proquest.com
A proliferating cell must grow, duplicate, and divide. Faithful duplication of DNA is required
to pass the genetic information to the daughter cell. DNA replication is a fundamental …
to pass the genetic information to the daughter cell. DNA replication is a fundamental …
Characterization of ATR kinase function in quiescent human keratinocytes when exposed to solar simulating UV radiation
HT Kadam - 2023 - rave.ohiolink.edu
Cell cycle control, DNA repair, and cell survival have all been linked to the ataxia-
telangiectasia and Rad3-related (ATR) kinase, a vital part of the DNA damage response …
telangiectasia and Rad3-related (ATR) kinase, a vital part of the DNA damage response …