The diverse cellular functions of inner nuclear membrane proteins
S Pawar, U Kutay - Cold Spring Harbor Perspectives in …, 2021 - cshperspectives.cshlp.org
The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …
The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin
Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe
are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an …
are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an …
LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells
M Gu, D LaJoie, OS Chen… - Proceedings of the …, 2017 - National Acad Sciences
Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been
implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in …
implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in …
Native chromatin proteomics reveals a role for specific nucleoporins in heterochromatin organization and maintenance
N Iglesias, JA Paulo, A Tatarakis, X Wang, AL Edwards… - Molecular cell, 2020 - cell.com
Spatially and functionally distinct domains of heterochromatin and euchromatin play
important roles in the maintenance of chromosome stability and regulation of gene …
important roles in the maintenance of chromosome stability and regulation of gene …
[HTML][HTML] ESCRT-III/Vps4 controls heterochromatin-nuclear envelope attachments
Eukaryotic genomes are organized within the nucleus through interactions with inner
nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in …
nuclear membrane (INM) proteins. How chromatin tethering to the INM is controlled in …
Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast
Y Hirano, Y Kinugasa, Y Kubota… - The Journal of …, 2023 - academic.oup.com
The nuclear envelope (NE) is a double-membrane structure consisting of inner and outer
membranes that spatially separate the nucleus from the cytoplasm, and its function is critical …
membranes that spatially separate the nucleus from the cytoplasm, and its function is critical …
Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation
Maintaining the integrity of the nuclear envelope (NE) is essential for preventing genomic
DNA damage. Recent studies have shown that enzymes that catalyze lipid synthesis are …
DNA damage. Recent studies have shown that enzymes that catalyze lipid synthesis are …
[HTML][HTML] Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway
IJ Lee, E Stokasimov, N Dempsey, JM Varberg… - Journal of Cell …, 2020 - rupress.org
The nuclear envelope (NE) undergoes dynamic remodeling to maintain NE integrity, a
process involving the inner nuclear membrane protein LEM2 recruiting CHMP7/Cmp7 and …
process involving the inner nuclear membrane protein LEM2 recruiting CHMP7/Cmp7 and …
Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum
Y Hirano, Y Kinugasa, H Osakada, T Shindo… - Communications …, 2020 - nature.com
The nuclear envelope (NE) continues to the endoplasmic reticulum (ER). Proper partitioning
of NE and ER is crucial for cellular activity, but the key factors maintaining the boundary …
of NE and ER is crucial for cellular activity, but the key factors maintaining the boundary …