Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
Hallmarks of health
C López-Otín, G Kroemer - Cell, 2021 - cell.com
Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …
as a compendium of organizational and dynamic features that maintain physiology. The …
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …
Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
Molecular mechanisms and physiological importance of circadian rhythms
A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
[HTML][HTML] Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair
Large bone defects resulting from fractures and disease are a major clinical challenge,
being often unable to heal spontaneously by the body's repair mechanisms. Lines of …
being often unable to heal spontaneously by the body's repair mechanisms. Lines of …
Circadian mechanisms in medicine
Circadian Mechanisms in Medicine Molecular insights into diurnal variations in human
physiology and behavior are extending our understanding of a wide range of disease …
physiology and behavior are extending our understanding of a wide range of disease …
Communicating clocks shape circadian homeostasis
KB Koronowski, P Sassone-Corsi - Science, 2021 - science.org
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
Circadian clocks and insulin resistance
DJ Stenvers, FAJL Scheer, P Schrauwen… - Nature Reviews …, 2019 - nature.com
Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …
major cause of morbidity and mortality. The circadian timing system consists of a central …
[HTML][HTML] Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is
expected to rise further, secondary to the growing aging, sedentary population. The strain on …
expected to rise further, secondary to the growing aging, sedentary population. The strain on …