Brain edema is a severe stroke complication that is associated with prolonged
hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral …

Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …

Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …

Background The BIN1 locus contains the second-most significant genetic risk factor for late-
onset Alzheimer's disease. BIN1 undergoes alternate splicing to generate tissue-and cell …

In the central nervous system (CNS), microglia are innate immune mononuclear phagocytes
(CNS MPs) that can phagocytose infectious particles, apoptotic cells, neurons, and …

Microglia show a rich repertoire of activation patterns regulated by a complex ensemble of
surface ion channels, receptors, and transporters. We and others have investigated whether …

Microglia provide immune surveillance of the CNS. They display diverse behaviors,
including nondirectional and directed motility of their processes, phagocytosis of targets …

Microglia significantly contribute to the pathophysiology of Alzheimer's disease but an
effective microglia-targeted therapeutic approach is not yet available clinically. The …

Neuroinflammation is a critical pathophysiological hallmark of neurodegenerative disorders,
including Alzheimer's disease (AD), Parkinson's disease (PD), and traumatic brain injury …