[HTML][HTML] Function and targeting of MALT1 paracaspase in cancer
TJ O'Neill, MJ Tofaute, D Krappmann - Cancer Treatment Reviews, 2023 - Elsevier
The paracaspase MALT1 has emerged as a key regulator of immune signaling, which also
promotes tumor development by both cancer cell-intrinsic and-extrinsic mechanisms. As an …
promotes tumor development by both cancer cell-intrinsic and-extrinsic mechanisms. As an …
Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages
B Zhou, Z Mo, G Lai, X Chen, R Li, R Wu, J Zhu… - Journal of Experimental …, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) have important regulatory functions in
cancer, but the role of circRNAs in the tumor microenvironment (TME) remains unclear …
cancer, but the role of circRNAs in the tumor microenvironment (TME) remains unclear …
The paracaspase MALT1 in cancer
B Gomez Solsona, A Schmitt, K Schulze-Osthoff… - Biomedicines, 2022 - mdpi.com
Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-
induced NF-κB activation was first described. Since then, several other immune receptors, G …
induced NF-κB activation was first described. Since then, several other immune receptors, G …
[HTML][HTML] Combining precision oncology and immunotherapy by targeting the MALT1 protease
TR Mempel, D Krappmann - Journal for ImmunoTherapy of Cancer, 2022 - ncbi.nlm.nih.gov
An innovative strategy for cancer therapy is to combine the inhibition of cancer cell-intrinsic
oncogenic signaling with cancer cell-extrinsic immunological activation of the tumor …
oncogenic signaling with cancer cell-extrinsic immunological activation of the tumor …
Post-translational modification of MALT1 and its role in B cell-and T cell-related diseases
YY Zhang, J Peng, XJ Luo - Biochemical Pharmacology, 2022 - Elsevier
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a
multifunctional protein. MALT1 functions as an adaptor protein to assemble and recruit …
multifunctional protein. MALT1 functions as an adaptor protein to assemble and recruit …
Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing
L Wittner, L Wagener, JJ Wiese, I Stolzer… - International journal of …, 2023 - mdpi.com
The paracaspase MALT1 is a crucial regulator of immune responses in various cellular
contexts. Recently, there is increasing evidence suggesting that MALT1 might represent a …
contexts. Recently, there is increasing evidence suggesting that MALT1 might represent a …
[HTML][HTML] Significance and possible biological mechanism for CLDN8 downregulation in kidney renal clear cell carcinoma tissues
HC Ji, J Di Li, GL Zhang, ZG Huang… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Background The clinical role of claudin 8 (CLDN8) in kidney renal clear cell carcinoma
(KIRC) remains unclarified. Herein, the expression level and potential molecular …
(KIRC) remains unclarified. Herein, the expression level and potential molecular …
Circular RNA circPTK2 modulates migration and invasion via miR-136/NFIB signaling on triple-negative breast cancer cells in vitro
M Wang, D Chen, H Zhang, C Luo - Inflammation Research, 2022 - Springer
Objective and background Triple-negative breast cancer (TNBC) is an aggressive breast
type of cancer with poor prognosis and high mortality rates. CircRNAs have been widely …
type of cancer with poor prognosis and high mortality rates. CircRNAs have been widely …
The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway
Y Wang, X Deng, J Xie, T Lu, R Qian, Z Guo… - Cell Biology and …, 2024 - Springer
MALT1 has been implicated as an upstream regulator of NF-κB signaling in immune cells
and tumors. This study determined the regulatory mechanisms and biological functions of …
and tumors. This study determined the regulatory mechanisms and biological functions of …
MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression
J Hofstatter Azambuja, SS Yerneni, LM Maurer… - bioRxiv, 2024 - biorxiv.org
MALT1 protease is an intracellular signaling molecule that promotes tumor progression via
cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied …
cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied …