The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

The increasing occurrence of obesity has become a significant public health concern.
Individuals with obesity have higher prevalence of heart disease, stroke, osteoarthritis …

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin …

Tanycytes are highly specialized ependymal cells that form a blood–cerebrospinal fluid
(CSF) barrier at the level of the median eminence (ME), a circumventricular organ (CVO) …

The chemical signalling molecule nitric oxide (NO), which freely diffuses through aqueous
and lipid environments, subserves an array of functions in the mammalian central nervous …

Natural fluctuations in physiological conditions require adaptive responses involving rapid
and reversible structural and functional changes in the hypothalamic neuroendocrine …

Reproductive competence in mammals depends on the projection of gonadotropin-
releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the …

Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival
of mammalian species by endowing brain neuronal networks with the ability to make …

Puberty is a process of transition from childhood to adult reproductive capacity, governed by
the reactivation of the hypothalamic–pituitary–gonadal axis after a long period of dormancy …

In vertebrates, folliculogenesis and ovulation are regulated by two distinct pituitary
gonadotropins: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Currently …