Matrix metalloproteinases, vascular remodeling, and vascular disease
X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading
M Kjaer - Physiological reviews, 2004 - journals.physiology.org
Kjær, Michael. Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to
Mechanical Loading. Physiol Rev 84: 649–698, 2004; 10.1152/physrev. 00031.2003.—The …
Mechanical Loading. Physiol Rev 84: 649–698, 2004; 10.1152/physrev. 00031.2003.—The …
Strategies for MMP inhibition in cancer: innovations for the post-trial era
CM Overall, C López-Otín - Nature Reviews Cancer, 2002 - nature.com
For more than two decades, the view that tumour-associated matrix metalloproteinases
(MMPs) were required for peritumour tissue degradation and metastasis dominated the drive …
(MMPs) were required for peritumour tissue degradation and metastasis dominated the drive …
Gelatinase-mediated migration and invasion of cancer cells
M Björklund, E Koivunen - Biochimica et Biophysica Acta (BBA)-Reviews …, 2005 - Elsevier
The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …
long recognized as major contributors to the proteolytic degradation of extracellular matrix …
Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
Cellular and molecular dynamics in the foreign body reaction
DT Luttikhuizen, MC Harmsen, MJAV Luyn - Tissue engineering, 2006 - liebertpub.com
Intracorporally implanted materials, such as medical devices, will provoke the body to initiate
an in-flammatory reaction. This inflammatory reaction to implanted materials is known as the …
an in-flammatory reaction. This inflammatory reaction to implanted materials is known as the …
[HTML][HTML] To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition
JA Jacobsen, JLM Jourden, MT Miller… - Biochimica et Biophysica …, 2010 - Elsevier
This short review highlights some recent advances in matrix metalloproteinase inhibitor
(MMPi) design and development. Three distinct approaches to improved MMP inhibition are …
(MMPi) design and development. Three distinct approaches to improved MMP inhibition are …
[HTML][HTML] Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American …
DT Azar - Transactions of the American Ophthalmological Society, 2006 - ncbi.nlm.nih.gov
Purpose To determine the molecular basis of corneal avascularity during wound healing
and determine the role of angiogenic and antiangiogenic factors in corneal vasculogenesis …
and determine the role of angiogenic and antiangiogenic factors in corneal vasculogenesis …
[HTML][HTML] Mechanisms of lower extremity vein dysfunction in chronic venous disease and implications in management of varicose veins
JD Raffetto, RA Khalil - Vessel plus, 2021 - ncbi.nlm.nih.gov
Chronic venous disease (CVD) is a common venous disorder of the lower extremities. CVD
can be manifested as varicose veins (VVs), with dilated and tortuous veins, dysfunctional …
can be manifested as varicose veins (VVs), with dilated and tortuous veins, dysfunctional …
Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation
B Annabi, YT Lee, S Turcotte, E Naud… - Stem …, 2003 - academic.oup.com
Recent evidence indicates that bone-marrow-derived stromal cells (MSCs) have a histology
coherent with endothelial cells that may enable them to contribute to tumor angiogenesis …
coherent with endothelial cells that may enable them to contribute to tumor angiogenesis …