Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects
S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …
Vitamin D-mediated regulation of intestinal calcium absorption
JC Fleet - Nutrients, 2022 - mdpi.com
Vitamin D is a critical regulator of calcium and bone homeostasis. While vitamin D has
multiple effects on bone and calcium metabolism, the regulation of intestinal calcium (Ca) …
multiple effects on bone and calcium metabolism, the regulation of intestinal calcium (Ca) …
The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease
N Stafford, C Wilson, D Oceandy… - Physiological …, 2017 - journals.physiology.org
The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane
calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of …
calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of …
Calcium selective channel TRPV6: Structure, function, and implications in health and disease
Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid
subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in …
subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in …
Dietary and pharmacological compounds altering intestinal calcium absorption in humans and animals
V Areco, MA Rivoira, V Rodriguez… - Nutrition research …, 2015 - cambridge.org
The intestine is the only gate for the entry of Ca to the body in humans and mammals. The
entrance of Ca occurs via paracellular and intracellular pathways. All steps of the latter …
entrance of Ca occurs via paracellular and intracellular pathways. All steps of the latter …
Improving equitability and inclusion for testing and detection of lead poisoning in US children
C Sobin, M GUTIéRREZ‐VEGA… - The Milbank …, 2023 - Wiley Online Library
Policy Points Child lead poisoning is associated with socioeconomic inequity and
perpetuates health inequality. Methods for testing and detection of child lead poisoning are …
perpetuates health inequality. Methods for testing and detection of child lead poisoning are …
Vitamin D: A critical regulator of intestinal physiology
S Christakos - Journal of Bone and Mineral Research Plus, 2021 - academic.oup.com
Calcium is required for the functioning of numerous biological processes and is essential for
skeletal health. The major source of new calcium is from the diet. The central role of vitamin …
skeletal health. The major source of new calcium is from the diet. The central role of vitamin …
True mineral digestibility in C57Bl/6J mice
Data on mineral digestibility is key to understand mineral homeostasis and refine the
recommendations for the dietary intake of these nutrients. In farm animals and pets, there is …
recommendations for the dietary intake of these nutrients. In farm animals and pets, there is …
Compensatory changes in calcium metabolism accompany the loss of vitamin D receptor (VDR) from the distal intestine and kidney of mice
PC Reyes‐Fernandez, JC Fleet - Journal of Bone and Mineral …, 2016 - academic.oup.com
ABSTRACT 1, 25 Dihydroxyvitamin D3 (1, 25 (OH) 2D) increases intestinal Ca absorption
when dietary Ca intake is low by inducing gene expression through the vitamin D receptor …
when dietary Ca intake is low by inducing gene expression through the vitamin D receptor …
Transgenic expression of the vitamin D receptor restricted to the ileum, cecum, and colon of vitamin D receptor knockout mice rescues vitamin D receptor− dependent …
P Dhawan, V Veldurthy, G Yehia, C Hsaio… - …, 2017 - academic.oup.com
Although the intestine plays the major role in 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3]
action on calcium homeostasis, the mechanisms involved remain incompletely understood …
action on calcium homeostasis, the mechanisms involved remain incompletely understood …