Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Pathophysiology of diabetes: An overview

MZ Banday, AS Sameer, S Nissar - Avicenna journal of …, 2020 - thieme-connect.com
Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …

An expanded genome-wide association study of type 2 diabetes in Europeans

RA Scott, LJ Scott, R Mägi, L Marullo, KJ Gaulton… - Diabetes, 2017 - Am Diabetes Assoc
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …

Genetic markers of type 2 diabetes: Progress in genome‐wide association studies and clinical application for risk prediction: 2 型糖尿病的遗传标记: 风险预测的全 …

X Wang, G Strizich, Y Hu, T Wang… - Journal of …, 2016 - Wiley Online Library
摘要2 型糖尿病已经成为全球公共卫生的主要挑战. 迄今为止, 通过全基因组关联研究(genome‐
wide association studies, GWAS) 总共已经鉴定出了83 个2 型糖尿病易感位点. 为了发现2 …

[HTML][HTML] Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention

Y Wu, Y Ding, Y Tanaka, W Zhang - International journal of medical …, 2014 - ncbi.nlm.nih.gov
Type 2 diabetes is a serious and common chronic disease resulting from a complex
inheritance-environment interaction along with other risk factors such as obesity and …

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

B Dinda, S Dinda, S DasSharma, R Banik… - European journal of …, 2017 - Elsevier
Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

A Xue, Y Wu, Z Zhu, F Zhang, KE Kemper… - Nature …, 2018 - nature.com
Abstract Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a
meta-analysis of genome-wide association studies (GWAS) with~ 16 million genetic variants …

Associations of combined genetic and lifestyle risks with incident cardiovascular disease and diabetes in the UK Biobank Study

MA Said, N Verweij, P van der Harst - JAMA cardiology, 2018 - jamanetwork.com
Importance Genetic and lifestyle factors both contribute to the risk of developing
cardiovascular disease, but whether poor health behaviors are associated with similar …

Diabetes, pancreatogenic diabetes, and pancreatic cancer

DK Andersen, M Korc, GM Petersen, G Eibl, D Li… - Diabetes, 2017 - Am Diabetes Assoc
The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are
complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but …

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …