Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …

Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent
cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is …

The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

This review article provides a historical perspective on the role of purinergic signalling in the
regulation of various subsets of immune cells from early discoveries to current …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Although inflammatory and immunological reactions protect the host from invasion by
microorganisms and eliminate debris at sites of tissue injury, they can also be responsible …