Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Mounting evidence indicates that microglial activation contributes to neuronal damage in
neurodegenerative diseases. Recent studies show that in response to certain environmental …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Neurodegenerative diseases are a group of chronic, progressive disorders characterized by
the gradual loss of neurons in discrete areas of the central nervous system (CNS). The …

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …

Deciphering what governs inflammation and its effects on tissues is vital for understanding
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …

Patients with major depressive disorder have elevated peripheral inflammation; the degree
of this increase correlates with the severity of the disorder. Chronic psychological stress …

The pathophysiology of cerebral ischemia involves multiple mechanisms including
neuroinflammation mediated by activated microglia and infiltrating macrophages/monocytes …