[HTML][HTML] Histone deacetylases inhibitors in neurodegenerative diseases, neuroprotection and neuronal differentiation
S Shukla, BL Tekwani - Frontiers in pharmacology, 2020 - frontiersin.org
Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …
of histones and non-histone proteins and regulate the process of transcription by binding to …
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …
schizophrenia, affect a significant percentage of the world population. These disorders are …
The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
ML Block, L Zecca, JS Hong - Nature Reviews Neuroscience, 2007 - nature.com
Mounting evidence indicates that microglial activation contributes to neuronal damage in
neurodegenerative diseases. Recent studies show that in response to certain environmental …
neurodegenerative diseases. Recent studies show that in response to certain environmental …
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …
disorder (BD), a severe mental illness arising from complex interactions between genes and …
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
HM Gao, JS Hong - Trends in immunology, 2008 - cell.com
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by
the gradual loss of neurons in discrete areas of the central nervous system (CNS). The …
the gradual loss of neurons in discrete areas of the central nervous system (CNS). The …
Multiple roles of HDAC inhibition in neurodegenerative conditions
DM Chuang, Y Leng, Z Marinova, HJ Kim… - Trends in neurosciences, 2009 - cell.com
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …
histones and other proteins and in regulating fundamental cellular activities such as …
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
Deciphering what governs inflammation and its effects on tissues is vital for understanding
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …
Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice
Y Yamawaki, N Yoshioka, K Nozaki, H Ito, K Oda… - Brain research, 2018 - Elsevier
Patients with major depressive disorder have elevated peripheral inflammation; the degree
of this increase correlates with the severity of the disorder. Chronic psychological stress …
of this increase correlates with the severity of the disorder. Chronic psychological stress …
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action
HJ Kim, M Rowe, M Ren, JS Hong, PS Chen… - … of Pharmacology and …, 2007 - ASPET
The pathophysiology of cerebral ischemia involves multiple mechanisms including
neuroinflammation mediated by activated microglia and infiltrating macrophages/monocytes …
neuroinflammation mediated by activated microglia and infiltrating macrophages/monocytes …