Objective: Research and clinical translation in schizophrenia is limited by inconsistent
definitions of treatment resistance and response. To address this issue, the authors …

BACKGROUND: Treatment-resistant major depressive disorder is a prevalent and
debilitating condition. Deep brain stimulation to different targets has been proposed as a …

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to
treatment. Despite evidence for the efficacy of multimodality interventions, the majority of …

Morosini P‐L, Magliano L, Brambilla L, Ugolini S, Pioli R. Development, reliability and
acceptability of a new version of the DSM‐IV Social and Occupational Functioning …

Elevations in peripheral inflammatory markers have been reported in patients with
psychosis. Whether this represents an inflammatory process defined by individual or …

BackgroundMusic therapy has previously been found to be effective in the treatment of
depression but the studies have been methodologically insufficient and lacking in clarity …

Background Second-generation antipsychotic drugs were introduced over a decade ago for
the treatment of schizophrenia; however, their purported clinical effectiveness compared …

Short-and long-term antidepressant effects of deep brain stimulation (DBS) in treatment-
resistant depression (TRD) have been demonstrated for several brain targets in open-label …

BackgroundThere is little consistency in how severe mental illness (SMI) is defined in
practice, and no operational definitions. AimsTo test two operationalised definitions, based …

Background The effect of cognitive behavioural therapy for psychosis (CBTp) on the core
symptoms of schizophrenia has proven contentious, with current meta-analyses finding at …