Identification of the growth cone as a probe and driver of neuronal migration in the injured brain
C Nakajima, M Sawada, E Umeda, Y Takagi… - Nature …, 2024 - nature.com
Axonal growth cones mediate axonal guidance and growth regulation. We show that
migrating neurons in mice possess a growth cone at the tip of their leading process, similar …
migrating neurons in mice possess a growth cone at the tip of their leading process, similar …
Enzymes of sphingolipid metabolism as transducers of metabolic inputs
FN Velazquez, C Luberto, D Canals… - Biochemical Society …, 2024 - portlandpress.com
Sphingolipids (SLs) constitute a discrete subdomain of metabolism, and they display both
structural and signaling functions. Accumulating evidence also points to intimate …
structural and signaling functions. Accumulating evidence also points to intimate …
Lipid Rafts: The Maestros of Normal Brain Development
Lipid rafts, specialised microdomains within cell membranes, play a central role in
orchestrating various aspects of neurodevelopment, ranging from neural differentiation to …
orchestrating various aspects of neurodevelopment, ranging from neural differentiation to …
Molecular mapping of neuronal architecture using STORM microscopy and new fluorescent probes for SMLM imaging
V Breton, P Nazac, D Boulet, L Danglot - Neurophotonics, 2024 - spiedigitallibrary.org
Imaging neuronal architecture has been a recurrent challenge over the years, and the
localization of synaptic proteins is a frequent challenge in neuroscience. To quantitatively …
localization of synaptic proteins is a frequent challenge in neuroscience. To quantitatively …
Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty acid elongation cycle and its cooperative action with fatty acid elongases
R Kato, Y Takenaka, Y Ohno, A Kihara - Journal of Biological Chemistry, 2024 - ASBMB
The fatty acid (FA) elongation cycle produces very-long-chain FAs with≥ C21, which have
unique physiological functions. Trans-2-enoyl-CoA reductases (yeast, Tsc13; mammals …
unique physiological functions. Trans-2-enoyl-CoA reductases (yeast, Tsc13; mammals …
A fatty acid elongase complex regulates cell membrane integrity and septin‐dependent host infection by the rice blast fungus
J Su, Y Xu, M Lei, Y Meng, S Zhang… - Molecular Plant …, 2024 - Wiley Online Library
Very‐long‐chain fatty acids (VLCFAs) regulate biophysical properties of cell membranes to
determine growth and development of eukaryotes, such as the pathogenesis of the rice blast …
determine growth and development of eukaryotes, such as the pathogenesis of the rice blast …
Sex-Dependent Variations in Hypothalamic Fatty Acid Profile and Neuropeptides in Offspring Exposed to Maternal Obesity and High-Fat Diet
MN Baqueiro, LAP Simino, JP Costa, C Panzarin… - Nutrients, 2024 - mdpi.com
Maternal obesity and/or high-fat diet (HF) consumption can disrupt appetite regulation in
their offspring, contributing to transgenerational obesity and metabolic diseases. As fatty …
their offspring, contributing to transgenerational obesity and metabolic diseases. As fatty …
Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?
C Lingwood - Lipids in Health and Disease, 2024 - Springer
Disturbances in cholesterol homeostasis have been associated with ASD. Lipid rafts are
central in many transmembrane signaling pathways (including mTOR) and changes in raft …
central in many transmembrane signaling pathways (including mTOR) and changes in raft …
Identification of z‐axis filopodia in growth cones using super‐resolution microscopy
M Nozumi, Y Sato, M Nishiyama‐Usuda… - Journal of …, 2024 - Wiley Online Library
A growth cone is a highly motile tip of an extending axon that is crucial for neural network
formation. Three‐dimensional‐structured illumination microscopy, a type of super‐resolution …
formation. Three‐dimensional‐structured illumination microscopy, a type of super‐resolution …
The Truncated Tropomyosin Kinase B Receptor Influences Feeding Behaviour, Cholesterol Production and Susceptibility to Stress in a Sex-Dependent Manner
N Prowse - 2024 - repository.library.carleton.ca
Brain-derived neurotrophic factor (BDNF), is known to promote neuroplastic changes that
facilitate many behaviors and may mitigate the impact of stressor exposure. BDNF signals …
facilitate many behaviors and may mitigate the impact of stressor exposure. BDNF signals …