Abstract Tripterygium wilfordii Hook F (TwHF)‐based therapy is among the most efficient and
crucial therapeutics for the treatment of rheumatoid arthritis (RA), which indicates that TwHF …

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was
recently implicated in various autoimmune disorders. Tregs are responsible for the …

Rheumatoid arthritis (RA) is a systemic inflammatory disorder which can cause bone and
cartilage damage leading to disability, yet the treatment remains unsatisfactory nowadays …

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

Triptolide and celastrol are predominantly active natural products isolated from the
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …

The immune system is one of the main defence mechanisms of the human body.
Inadequacy of this system or immunodeficiency results in increased risk of infections and …

Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling
of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and …

Summary T helper type 17 (Th17) and regulatory T (Treg) cells are active players in the
establishment of tolerance and defence. These attributes of the immune system enmesh to …

Background Celastrol, a pentacyclic triterpenoid quinonemethide isolated from several spp.
of Celastraceae family, exhibits anti-inflammatory activities in a variety of diseases including …