Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment: integrated computational analysis and in vitro study
The treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the
brain, the limited capacity of brain cells to repair, resistance to conventional therapy, and its …
brain, the limited capacity of brain cells to repair, resistance to conventional therapy, and its …
Preparation and cytotoxic evaluation of PGV-1 derivative, CCA-1.1, as a new curcumin analog with improved-physicochemical and pharmacological properties
Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1
(PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) …
(PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) …
[HTML][HTML] CCA-1.1, a novel curcumin analog, exerts cytotoxic anti-migratory activity toward TNBC and HER2-enriched breast cancer cells
Objective: Chemoprevention curcumin Analog-1.1 (CCA-1.1) demonstrates antineoplastic
effect toward cancer cells. By using triple-negative breast cancer (TNBC), 4T1, and human …
effect toward cancer cells. By using triple-negative breast cancer (TNBC), 4T1, and human …
[HTML][HTML] Cytoprotective properties of citronella oil (Cymbopogon nardus (L.) Rendl.) and lemongrass oil (Cymbopogon citratus (DC.) Stapf) through attenuation of …
DU Salsabila, RK Wardani, NU Hasanah… - Asian Pacific Journal …, 2023 - ncbi.nlm.nih.gov
Objective: This study aimed to determine the cytoprotective potentials of citronella
(Cymbopogon nardus (L.) Rendl.) essential oil (CO) and lemongrass (Cymbopogon citratus …
(Cymbopogon nardus (L.) Rendl.) essential oil (CO) and lemongrass (Cymbopogon citratus …
[HTML][HTML] Piperine increases pentagamavunon-1 anti-cancer activity on 4T1 breast cancer through mitotic catastrophe mechanism and senescence with sharing …
Pentagamavunon-1 performs more potent anti-cancer effects than curcumin against various
cancer cells, but it remains to be optimized. Piperine shows the activity as an enhancer of a …
cancer cells, but it remains to be optimized. Piperine shows the activity as an enhancer of a …
Curcumin analogs, PGV-1 and CCA-1.1 exhibit anti-migratory effects and suppress MMP9 expression on WiDr cells
F Wulandari, M Kirihata, JY Kato… - The Indonesian …, 2021 - inabj.tjahajabaroe.com
BACKGROUND: Colon cancer is still a crucial concern in the development of
chemotherapeutic drugs due to the drug resistance phenomenon and various side effects to …
chemotherapeutic drugs due to the drug resistance phenomenon and various side effects to …
A new curcumin analog, CCA-1.1, induces cell death and cell cycle arrest in WiDr colon cancer cells via ROS generation
Abstract The new Pentagamavunone-1 (PGV-1) derivative, chemoprevention-curcumin
analog 1.1 (CCA-1.1), is described as an improved physicochemical feature with similar …
analog 1.1 (CCA-1.1), is described as an improved physicochemical feature with similar …
The integrative bioinformatic analysis deciphers the predicted molecular target gene and pathway from curcumin derivative CCA-1.1 against triple-negative breast …
D Novitasari, RI Jenie, J Kato, E Meiyanto - Journal of the Egyptian …, 2021 - Springer
Background The poor outcomes from triple-negative breast cancer (TNBC) therapy are
mainly because of TNBC cells' heterogeneity, and chemotherapy is the current approach in …
mainly because of TNBC cells' heterogeneity, and chemotherapy is the current approach in …
Network pharmacological analysis identifies the curcumin analog CCA-1.1 targeting mitosis regulatory process in HER2-positive breast cancer
D Novitasari, RI Jenie, J Kato… - Indonesian Journal of …, 2023 - journal.ugm.ac.id
Recent studies present that the CCA-1.1 (a curcumin derivative) impedes the proliferation of
breast cancer cells (luminal, HER2-overexpressed, and TNBC cells). Currently, we analyze …
breast cancer cells (luminal, HER2-overexpressed, and TNBC cells). Currently, we analyze …
Stability-indicating RP-HPLC method development and validation for simultaneous estimation of bisoprolol fumarate and amlodipine besylate in bulk and in tablet …
RB Gholve, SS Pekamwar… - Journal of Applied …, 2021 - japsonline.com
A novel chromatographic method has been developed with a stability-indicating feature for
simultaneous estimation of bisoprolol fumarate (BSL) and amlodipine besylate (AMD) in …
simultaneous estimation of bisoprolol fumarate (BSL) and amlodipine besylate (AMD) in …