Anticoagulants have exhibited a critical role in the prevention and/or treatment of thrombotic
diseases. Up to now, kinds of novel oral anticoagulants, inhibiting plasma serine proteases …

Thrombosis is one of the most important pathogenic factors related to cardiovascular
diseases. Presently, thrombin inhibitors have gradually gained prominence in clinical …

Despite extensive research on small molecule thrombin inhibitors for oral application in the
past decades, only a single double prodrug with very modest oral bioavailability has …

Introduction Hepatic carcinoma (HCC) is one of the most lethal malignant tumors in the
world, and new treatment regimens for this disease are urgently needed. Studies have …

Introduction High incidence of bleeding events remains a key risk for patients taking
anticoagulants, especially those in need of long-term combination therapy with antiplatelet …

A combinatorial method was devised and applied for the design and identification of
substrate-analogue inhibitors of therapeutically relevant serine proteases, such as thrombin …