Cellular senescence is a state comprising an essentially irreversible proliferative arrest
combined with phenotypic changes and pronounced secretory activity. Although …

The idea that senescent cells are causally involved in aging has gained strong support from
findings that the removal of such cells alleviates many age‐related diseases and extends …

Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …

It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

During vertebrate embryonic development, cellular senescence occurs at multiple locations.
To date, it has been accepted that when there has been induction of senescence in an …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Here, we provide an overview of the importance of cellular fate in cancer as a group of
diseases of abnormal cell growth. Tumor development and progression is a highly dynamic …

Senescence is a cellular state which involves cell cycle arrest and a proinflammatory
phenotype, and it has traditionally been associated with cellular and organismal aging …

Cellular senescence, once thought an artifact of in vitro culture or passive outcome of aging,
has emerged as fundamental to tissue development and function. The senescence …