Surgery, chemotherapy, radiotherapy, and hormone therapy are the main common anti-
tumor therapeutic approaches. However, the non-specific targeting of cancer cells has made …

Novel nanomaterials are being developed to improve diagnosis and therapy of diseases
through effective delivery of drugs, biopharmaceutical molecules and imaging agents to …

Signal transduction is initiated by complex protein–protein interactions between ligands,
receptors and kinases, to name only a few. It is now becoming clear that lipid micro …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Endocytosis occurs at the cell surface and involves internalization of the plasma membrane
(PM) along with its constituent membrane proteins and lipids. Endocytosis is involved in …

This article aims at providing an update on the complexity of clathrin-independent
endocytosis. It is now almost 30 years since we first wrote a review about its existence; at …

Cholesterol plays an indispensable role in regulating the properties of cell membranes in
mammalian cells. Recent advances suggest that cholesterol exerts many of its actions …

The importance of cholesterol for endocytosis has been investigated in HEp-2 and other cell
lines by using methyl-β-cyclodextrin (MβCD) to selectively extract cholesterol from the …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

Endocytosis of cell-surface proteins via specific pathways is critical for their function. We
show that multiple glycosylphosphatidylinositol-anchored proteins (GPI-APs) are …