Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Antunes-Rodrigues, José, Margaret de Castro, Lucila LK Elias, Marcelo M. Valença, and
Samuel M. McCann. Neuroendocrine Control of Body Fluid Metabolism. Physiol Rev 84: 169 …

Structural remodelling occurring before, due to the underlying heart disease, and during
atrial fibrillation (AF) sets the stage for permanent AF. Current therapy in AF aims to maintain …

Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals,
including renal hemodynamics, neuroendocrine, and cardiovascular functions. Collectively …

The precise regulation of cell growth in the vascular wall maintains vascular integrity, and its
disruption leads to cardiovascular disorders including atherosclerosis and restenosis …

The current study tested the hypothesis that exposure to hypoxia enhances endothelin-1 (ET-
1) gene expression and elevates circulating ET-1 levels in the rat. Rats were exposed to …

A small GTPase, Rho, participates in agonist‐induced cytoskeletal organization and gene
expression in many cell types including cardiac myocytes. However, little is known about the …

Background—The mechanism responsible for cardiac hypertrophy is currently
conceptualized as having 2 components, mediated by cardiac myocytes and nonmyocytes …

The data reviewed establish the presence and important role in body fluid homeostasis of
brain atrial natriuretic peptide (ANP) in all vertebrate-species examined. The peptide is …

Adult mammalian ventricular cardiomyocytes are terminally differentiated cells that enlarge
adaptively by hypertrophy. In this situation, genes normally expressed in the fetal ventricular …