The scales, mechanisms, and dynamics of the genome architecture
L Lizana, YB Schwartz - Science Advances, 2024 - science.org
Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …
[HTML][HTML] Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
[HTML][HTML] Single-cell, whole-embryo phenotyping of mammalian developmental disorders
Mouse models are a critical tool for studying human diseases, particularly developmental
disorders. However, conventional approaches for phenotyping may fail to detect subtle …
disorders. However, conventional approaches for phenotyping may fail to detect subtle …
Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians
Abstract Information on how 3D genome topology emerged in animal evolution, how stable it
is during development, its role in the evolution of phenotypic novelties and how exactly it …
is during development, its role in the evolution of phenotypic novelties and how exactly it …
[HTML][HTML] TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function
M Okhovat, J VanCampen, KA Nevonen… - Nature …, 2023 - nature.com
Topological associating domains (TADs) are self-interacting genomic units crucial for
shaping gene regulation patterns. Despite their importance, the extent of their evolutionary …
shaping gene regulation patterns. Despite their importance, the extent of their evolutionary …
Chromosome evolution in Lepidoptera
Chromosomes are a central unit of genome organisation. One tenth of all described species
on Earth are Lepidoptera, butterflies and moths, and these generally possess 31 holocentric …
on Earth are Lepidoptera, butterflies and moths, and these generally possess 31 holocentric …
[HTML][HTML] TAD boundary deletion causes PITX2-related cardiac electrical and structural defects
While 3D chromatin organization in topologically associating domains (TADs) and loops
mediating regulatory element-promoter interactions is crucial for tissue-specific gene …
mediating regulatory element-promoter interactions is crucial for tissue-specific gene …
[HTML][HTML] Super-enhancers and their parts: from prediction efforts to pathognomonic status
AV Vasileva, MG Gladkova, GA Ashniev… - International Journal of …, 2024 - mdpi.com
Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene
expression by promoting large-scale transcriptional responses in various cell types and …
expression by promoting large-scale transcriptional responses in various cell types and …
[HTML][HTML] TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene
E Kabirova, A Ryzhkova, V Lukyanchikova… - Nature …, 2024 - nature.com
Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby
maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the …
maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the …
[HTML][HTML] Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently
no disease-modifying treatment options available. Mutations in GRN are one of the most …
no disease-modifying treatment options available. Mutations in GRN are one of the most …