The cellular and molecular bases of leptin and ghrelin resistance in obesity

H Cui, M López, K Rahmouni - Nature Reviews Endocrinology, 2017 - nature.com
Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

MR Junttila, SP Li, J Westermarck - The FASEB Journal, 2008 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) pathways constitute a large modular network that
regulates a variety of physiological processes, such as cell growth, differentiation, and …

Radiation-induced EGFR-signaling and control of DNA-damage repair

HP Rodemann, K Dittmann… - International journal of …, 2007 - Taylor & Francis
Purpose: Over the last decade evidence has accumulated indicating that cell membrane-
bound growth factor receptor of the erbB family and especially the epidermal growth factor …

Substrate-trapping techniques in the identification of cellular PTP targets

C Blanchetot, M Chagnon, N Dube, M Halle… - Methods, 2005 - Elsevier
Tyrosine phosphorylation is negatively regulated by the protein-tyrosine phosphatases
(PTPs). In order to find the physiological substrates of these enzymes, diverse PTP mutants …

Multiple leptin signalling pathways in the control of metabolism and fertility: a means to different ends?

MC Evans, RA Lord, GM Anderson - International Journal of Molecular …, 2021 - mdpi.com
The adipocyte-derived 'satiety promoting'hormone, leptin, has been identified as a key
central regulator of body weight and fertility, such that its absence leads to obesity and …

MicroRNA‐181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells

L Liu, Y Wang, H Fan, X Zhao, D Liu, Y Hu… - Stem …, 2012 - academic.oup.com
Mesenchymal stem cells (MSCs) exhibit extensive self‐renewal potential and can modulate
immunocyte activation. Our previous study reported that miR‐181a expression was …

Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs

P Heneberg - Current medicinal chemistry, 2009 - ingentaconnect.com
Protein tyrosine phosphatases (PTPs) are considered to be involved in the etiology of
diabetes mellitus, neural diseases such as Alzheimer's and Parkinson's disease, regulation …

Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat

JL Cadet, C Brannock, S Jayanthi, IN Krasnova - Molecular neurobiology, 2015 - Springer
Methamphetamine use disorder is a chronic neuropsychiatric disorder characterized by
recurrent binge episodes, intervals of abstinence, and relapses to drug use. Humans …

Central regulation of metabolism by protein tyrosine phosphatases

RC Tsou, KK Bence - Frontiers in Neuroscience, 2013 - frontiersin.org
Protein tyrosine phosphatases (PTPs) are important regulators of intracellular signaling
pathways via the dephosphorylation of phosphotyrosyl residues on various receptor and …

Molecular mechanism: ERK signaling, drug addiction, and behavioral effects

WL Sun, PM Quizon, J Zhu - … in molecular biology and translational science, 2016 - Elsevier
Addiction to psychostimulants has been considered as a chronic psychiatric disorder
characterized by craving and compulsive drug seeking and use. Over the past two decades …