[HTML][HTML] Viral quasispecies complexity measures
Mutant spectrum dynamics (changes in the related mutants that compose viral populations)
has a decisive impact on virus behavior. The several platforms of next generation …
has a decisive impact on virus behavior. The several platforms of next generation …
[HTML][HTML] Modulation of host lipid metabolism by hepatitis C virus: Role of new therapies
JA Del Campo, M Romero-Gómez - World Journal of …, 2015 - ncbi.nlm.nih.gov
It is well established that hepatitis C virus (HCV) infection and replication relies on host lipid
metabolism. HCV proteins interact and associate with lipid droplets to facilitate virion …
metabolism. HCV proteins interact and associate with lipid droplets to facilitate virion …
Inference with viral quasispecies diversity indices: clonal and NGS approaches
Given the inherent dynamics of a viral quasispecies, we are often interested in the
comparison of diversity indices of sequential samples of a patient, or in the comparison of …
comparison of diversity indices of sequential samples of a patient, or in the comparison of …
Quasispecies fitness partition to characterize the molecular status of a viral population. Negative effect of early ribavirin discontinuation in a chronically infected HEV …
The changes occurring in viral quasispecies populations during infection have been
monitored using diversity indices, nucleotide diversity, and several other indices to …
monitored using diversity indices, nucleotide diversity, and several other indices to …
Advanced molecular surveillance of hepatitis C virus
LM Goncalves Rossi, A Escobar-Gutierrez, P Rahal - Viruses, 2015 - mdpi.com
Hepatitis C virus (HCV) infection is an important public health problem worldwide. HCV
exploits complex molecular mechanisms, which result in a high degree of intrahost genetic …
exploits complex molecular mechanisms, which result in a high degree of intrahost genetic …
Mitochondrial DNAs decreased and correlated with clinical features in HCV patients from Yunnan, China
AM Zhang, K Ma, Y Song, Y Feng, H Duan… - … DNA Part A, 2016 - Taylor & Francis
Hepatitis C was the most popular chronic infectious liver disease worldwide. It was identified
that Hepatitis C virus (HCV) infection could lead to mitochondrial dysfunction, though the …
that Hepatitis C virus (HCV) infection could lead to mitochondrial dysfunction, though the …
Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection
J Ampuero, JA Del Campo, L Rojas… - Genes & …, 2015 - nature.com
Host–viral genetic interaction has a key role in hepatitis C infection (HCV) and maybe in the
viral selection. In a preliminary GWAS analysis, we identified BTN3A2 rs9104 to be …
viral selection. In a preliminary GWAS analysis, we identified BTN3A2 rs9104 to be …
Clinical, virological characteristics, and outcomes of treatment with sofosbuvir/ledipasvir in two pediatric patients infected by HCV genotype 4
N Marascio, M Mazzitelli, G Pavia, A Giancotti… - Cells, 2019 - mdpi.com
Direct-acting antiviral drugs to cure infections with Hepatitis C virus (HCV) achieve a
sustained virological response (SVR) in more than 90% of adult patients. At present, clinical …
sustained virological response (SVR) in more than 90% of adult patients. At present, clinical …
Influence of amino acid variations in the NS3, NS4A and NS4B of HCV genotypes 1a, 1b, 3a, 3b and 6f on the response to pegylated interferon and ribavirin …
P Chusri, K Kumthip, C Pantip, S Thongsawat… - Virus research, 2015 - Elsevier
Background It has been suggested that HCV proteins, core, NS3/4A, NS4B, and NS5A,
contribute to the resistance of HCV to IFN and ribavirin (RBV) treatments. Aim To assess the …
contribute to the resistance of HCV to IFN and ribavirin (RBV) treatments. Aim To assess the …
The antigenic variability of HCV in viral HLA-Ag binding is related to the activation of the host immune response
P Munoz de Rueda, SM Jiménez-Ruiz, R Quiles… - Scientific Reports, 2017 - nature.com
Our previous data show that hepatitis C virus (HCV) genotype 1 patients expressing the HLA-
DQB1* 0301 allele have a combined response probability of 69%, while the remaining 31 …
DQB1* 0301 allele have a combined response probability of 69%, while the remaining 31 …