Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

Stroke is the third cause of death worldwide and the main cause of chronic, severe adult
disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all …

Adult mammalian brains have largely lost neuroregeneration capability except for a few
niches. Previous studies have converted glial cells into neurons, but the total number of …

The reticulon family has been found to induce apoptosis, inhibit axon regeneration and
regulate protein trafficking. However, little is known about the mechanisms of how reticulon …

Stroke may cause severe death and disability but many clinical trials have failed in the past,
partially because the lack of an effective method to regenerate new neurons after stroke. In …

Traumatic brain injury (TBI) is acquired from an external force, which can inflict devastating
effects to the brain vasculature and neighboring neuronal cells. Disruption of vasculature is …

The interplay between lncRNAs and miRNAs was reported to be associated with cerebral
ischemia reperfusion injury (CIRI). Besides, the lncRNA ZFAS1 was significantly …

Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain
tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics …

Our team's pharmacological and clinical trials proved that ligustrazine/borneol spray had a
definite effect on ischemic stroke (IS). To solve the shortcomings of ligustrazine/borneol …

Activated microglia/macrophages significantly contribute to the secondary inflammatory
damage in ischemic stroke. Cultured neonatal microglia express the K+ channels Kv1. 3 and …