Anthelmintic resistance is reported in equine nematodes with increasing frequency in recent
years, and no new anthelmintic classes have been introduced during the past 40 years. This …

The avermectins and milbemycins contain a common macrocyclic lactone (ML) ring, but are
fermentation products of different organisms. The principal structural difference is that …

Macrocyclic lactones have been the most widely used drugs for equine parasite control
during the past four decades. Unlike ivermectin, moxidectin exhibits efficacy against …

A study in healthy male volunteers was completed to evaluate the safety, tolerability, and
pharmacokinetics of a single oral dose of the antiparasitic moxidectin (MOX). This drug is …

Internal parasites of horses comprise an intractable problem conferring disease, production
and performance losses. Parasitism can rarely be controlled in grazing horses by …

The macrocyclic lactones have pharmacokinetic properties which enhance their use against
endo-and ectoparasites in animals and man. The most consistent physico-chemical feature …

Parasitic nematodes, particularly cyathostomins, are ubiquitous in grazing horses world-
wide. Considerable burdens of cyathostomin larvae can encyst in the large intestinal wall …

The present study was carried out to investigate whether the pharmacokinetics of
avermectins or a milbemycin could explain their known or predicted efficacy in the horse …

This study compares plasma disposition kinetics of ivermectin and moxidectin after oral
administration to beagle dogs experimentally infected with the filarial parasite, Brugia …

The naturally occurring avermectin and milbemycin compounds are closely related 16-
membered macrocyclic lactones (MLs)(Burg et al., 1979; Takiguchi et al., 1980). Both …